| 新生儿抗生素相关性腹泻危险因素的Meta-分析 |
| |
| 引用本文： | 丁瑛,彭芝萍,吴赛君,吴秋敏.新生儿抗生素相关性腹泻危险因素的Meta-分析[J].现代药物与临床,2019,42(4):753-760. |
| |
| 作者姓名： | 丁瑛 彭芝萍 吴赛君 吴秋敏 |
| |
| 作者单位： | 孝感市中心医院(武汉科技大学附属孝感医院)静配中心, 湖北 孝感 432000,孝感市中心医院(武汉科技大学附属孝感医院)静配中心, 湖北 孝感 432000,孝感市中心医院(武汉科技大学附属孝感医院)静配中心, 湖北 孝感 432000,孝感市中心医院(武汉科技大学附属孝感医院)静配中心, 湖北 孝感 432000 |
| |
| 摘 要： | 目的 系统评价新生儿发生抗生素相关性腹泻（AAD）的危险因素，为临床提供循证医学证据。方法 检索PubMed、Embase、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、维普中文科技期刊数据库（VIP）和万方数据库等相关数据库，收集新生儿发生AAD危险因素的病例对照研究，检索时限为2000年1月-2018年5月，应用Rev Man 5.2软件进行Meta-分析。结果 共纳入13篇文献，涉及4 273例新生儿，其中AAD组915例，非AAD组3 358例。Meta-分析结果显示：低胎龄（SMD=-0.89，95%CI=-1.16~-0.61，P<0.01），出生时体质量偏小（SMD=-0.79，95%CI=-0.98~-0.59，P<0.01），日龄偏小（SMD=-1.08，95%CI=-1.20~-0.96，P<0.01），抗生素种类（SMD=1.59，95%CI=1.24~1.94，P<0.01），侵袭性操作（OR=2.06，95%CI=1.85~2.23，P<0.01），住院天数（SMD=2.21，95%CI=1.86~2.56，P<0.01）和非纯母乳喂养（OR=0.47，95%CI=0.38~9.57，P<0.01）是新生儿发生AAD的危险因素，抗生素预防用药（OR=1.17，95%CI=0.94~1.46，P>0.05）与新生儿发生AAD无关。结论 低胎龄、出生时体质量偏小、日龄小、多种抗生素联合用药、住院时间过长、侵袭性操作和非纯母乳喂养是新生儿发生AAD的危险因素。
|
| 关 键 词： | 新生儿 抗生素相关性腹泻 病例对照研究 危险因素 Meta-分析 |
| 收稿时间： | 2018/10/27 0:00:00 |
Meta-analysis of risk factors for antibiotic-associated diarrhea in neonates |
| |
| DING Ying,PENG Zhiping,WU Saijun and WU Qiumin.Meta-analysis of risk factors for antibiotic-associated diarrhea in neonates[J].Drugs & Clinic,2019,42(4):753-760. |
| |
| Authors: | DING Ying PENG Zhiping WU Saijun and WU Qiumin |
| |
| Affiliation: | Department of Pharmacy Intravenous Admixture Services, Xiaogan Central Hospital Xiaogan Hospital affiliated to Wuhan University of Science and Technology, Xiaogan 432000, China,Department of Pharmacy Intravenous Admixture Services, Xiaogan Central Hospital Xiaogan Hospital affiliated to Wuhan University of Science and Technology, Xiaogan 432000, China,Department of Pharmacy Intravenous Admixture Services, Xiaogan Central Hospital Xiaogan Hospital affiliated to Wuhan University of Science and Technology, Xiaogan 432000, China and Department of Pharmacy Intravenous Admixture Services, Xiaogan Central Hospital Xiaogan Hospital affiliated to Wuhan University of Science and Technology, Xiaogan 432000, China |
| |
| Abstract: | Objective To evaluate the risk factors for antibiotic-associated diarrhea (AAD) in neonates,and to provide evidencebased medical for clinical.Method The related databases of PubMed,Embase,CNKI,CBM,VIP and Wanfang Data were electronically searched for the case-control studies about risk factors for AAD in neonates from January 2010 to May 2018.Metaanalysis was conducted by RevMan 5.2 Software.Results A total of 13 studies involving 4 273 patients were studied,including 915 in the AAD group and 3 358 in the non-AAD group.The result of Meta-analysis showed that,the lower gestational age (SMD=-0.89,95%CI=-1.16~-0.61,P<0.01),lower birth weight (SMD=-0.79,95%CI=-0.98~-0.59,P<0.01),lower days age (SMD=-1.08,95%CI=-1.20~-0.96,P<0.01),combination of antibiotic (SMD=1.59,95%CI=1.24~1.94,P<0.01),longer hospital stay (SMD=2.21,95%CI=1.86~2.56,P<0.01),Invasive procedures (OR=2.06,95%CI=1.85~2.23,P<0.01) and non-pure breastfeeding (OR=0.47,95%CI=0.38~9.57,P<0.01) were risk factors for AAD in neonates,and prevention of antibiotic (OR=1.17,95%CI=0.94~1.46,P>0.05) was no risk factor for AAD in neonates.Conclusion Lower gestational age,lower birth weight,lower age,combination of antibiotics,longer hospital stay,Invasive procedures and non-pure breastfeeding are risk factors for AAD in neonates. |
| |
| Keywords: | neonates antibiotic-associated diarrhea (AAD) case-control studies risk factor Meta-analysis |
|
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
|
点击此处可从《现代药物与临床》下载全文 |
|
