| 周氏芪凌汤联合艾迪注射液治疗去势抵抗性前列腺癌的临床疗效研究 |
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| 引用本文： | 陈磊,曹宏文,高人杰,郁超,何晓锋,赵友康,孙鹏,周智恒,龚华,王丹,冯懿赓.周氏芪凌汤联合艾迪注射液治疗去势抵抗性前列腺癌的临床疗效研究[J].安徽医药,2019,23(5):1001-1005. |
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| 作者姓名： | 陈磊 曹宏文 高人杰 郁超 何晓锋 赵友康 孙鹏 周智恒 龚华 王丹 冯懿赓 |
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| 作者单位： | 上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032;上海中医药大学附属龙华医院泌尿外科,上海,200032 |
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| 基金项目： | 上海中医药大学附属龙华医院第三批中青年名中医培养项目(RC-2017-01-14) |
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| 摘 要： | 目的 观察探析周氏芪凌汤、艾迪注射液联合疗法对去势抵抗性前列腺癌(CRPC)的临床疗效。方法 以2016年1月至2017年6月间上海中医药大学附属龙华医院收治的51例CRPC病人作为研究对象,双盲法随机分为对照组(25例)和联合组(26例)。均进行常规治疗,包括双侧睾丸切除及全雄激素阻断治疗。另外,对照组静脉滴注艾迪注射液50 mL,每日1次。联合组在对照组治疗基础上联合口服自拟“周氏芪凌汤”,随症加减。经过4个疗程(2个月)的治疗后,观察比较两组病人治疗前后的血清PSA、最大尿流速、KPS、VAS变化和不良反应情况及治疗有效率。结果 治疗后联合组前列腺体积显著缩小(体积缩小约10%),且与对照组相比,差异有统计学意义(P＜0.05);比较两组病人治疗前血清PSA、最大尿流速、KPS及VAS指标发现,差异无统计学意义(P＞0.05);但两组病人治疗后上述指标较治疗前均有所改善(P＜0.05),且联合组改善更为明显,差异有统计学意义(P＜0.05);对比两组病人的不良反应情况发现,除了恶心呕吐、贫血两组比较差异无统计学意义外,联合组在骨质疏松、骨髓抑制、去势综合征及下肢水肿上与对照组对比,均差异有统计学意义(P＜0.05);经过连续4个疗程的治疗后,对照组有效率和病情控制率分别为12.00%和48.00%,而联合组则分别为23.08%和57.69%,两组比较差异有统计学意义(P＜0.05)。结论 周氏芪凌汤联合艾迪注射液治疗CRPC可有效改善病人相关临床指标,提高疗效的同时还可减少并发症的发生,对病人的预后具有一定意义,临床值得推广运用。
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| 关 键 词： | 前列腺肿瘤 睾丸切除术 中医治法 黄芪 冬凌草 人参 斑蝥 治疗结果 周氏芪凌汤 艾迪注射液 |
Study on clinical effect of Zhou Qi Ling decoction combined with Aidi injection in the treatment of castration resistant prostate cancer |
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| CHEN Lei,CAO Hongwen,GAO Renjie,YU Chao,HE Xiaofeng,ZHAO Youkang,SUN Peng,ZHOU Zhiheng,GONG Hu,WANG Dan and FENG Yigeng.Study on clinical effect of Zhou Qi Ling decoction combined with Aidi injection in the treatment of castration resistant prostate cancer[J].Anhui Medical and Pharmaceutical Journal,2019,23(5):1001-1005. |
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| Authors: | CHEN Lei CAO Hongwen GAO Renjie YU Chao HE Xiaofeng ZHAO Youkang SUN Peng ZHOU Zhiheng GONG Hu WANG Dan and FENG Yigeng |
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| Affiliation: | Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China and Department of Urinary Surgery,LongHua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China |
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| Abstract: | |
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| Keywords: | Prostatic neoplasms Orchiectomy Therapeutic methods (TCM) Astragalus membranaceus Rabdosia rubescens Ginseng Mylabris Treatment outcome Zhou Qi Ling decoction Aidi injection |
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