| c-myc基因重排对弥漫大B细胞淋巴瘤预后影响的Meta分析 |
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| 引用本文： | 王晓江,林贤东,何银珠,师怡,陈宝珍,陈刚. c-myc基因重排对弥漫大B细胞淋巴瘤预后影响的Meta分析[J]. 白血病．淋巴瘤, 2016, 25(1): 61-64. DOI: 10.3760/cma.j.issn.1009-9921.2016.01.017 |
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| 作者姓名： | 王晓江 林贤东 何银珠 师怡 陈宝珍 陈刚 |
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| 作者单位： | 福建省肿瘤医院分子病理研究室, 福州,350014;350014 福州,福建省肿瘤医院分子病理研究室;350014 福州,福建省肿瘤医院转化医学实验室;350014 福州,福建省肿瘤医院转化医学实验室;350014 福州,福建省肿瘤医院病理科 |
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| 基金项目： | 福建省医学创新课题(2012-cx-7) Fund program:Medical Innovation Project of Fujian Province (2012-cx-7) |
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| 摘 要： | 目的探讨c-myc基因重排对弥漫大B细胞淋巴瘤（DLBCL）远期疗效的影响，为DLBCL预后判断提供循证医学依据。方法计算机检索中英文数据库，收集国内外公开发表的关于c-myc基因重排DLBCL的相关文献，采用RevMan5．2软件进行Meta分析。结果筛选文献，共有8篇纳入研究。Meta分析显示，c-myc重排阳性的DLBCL患者5年无进展生存和总生存较c-myc重排阴性患者差（HR=2．28，95％CI 1．64～3．18；lib=2．35，95％CI1．93～2．85）。结论c-myc基因重排是潜在的DLBCL预后不良的生物标志物。
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| 关 键 词： | 基因 c—myc 淋巴瘤 大B一细胞 弥漫性 预后 Meta分析 |
Meta analysis of prognosis in diffuse large B-cell lymphoma patients with c-myc gene rearrangement |
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| Abstract: | Objective To investigate the significance of c-myc gene rearrangement on the long term efficacy of diffuse large B-cell lymphoma (DLBCL), and to provide the evidence-based medicine for prognosis of DLBCL. Methods The Chinese and English database were searched to identify all the articles about the DLBCL with c-myc gene rearrangement by computer. Meta-analysis was completed by RevMan 5.2 software. Results A total of eight studies were included. The Meta-analysis results displayed that DLBCL patients with c-myc gene rearrangement had the poor prognosis. Five years progression free survival (PFS) and overall survival (OS) were significantly worse (HR= 2.28, 95 %CI 1.64-3.18 and HR= 2.35, 95 %CI 1.93-2.85). Conclusion C-myc gene rearrangement is a potential biomarker for the poor prognosis of DLBCL. |
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| Keywords: | Gene c-myc Lymphoma large B-cell diffuse Prognosis Meta analysis |
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