降脂通络软胶囊联合瑞舒伐他汀对2型糖尿病合并高脂血症患者效果观察? |
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引用本文: | 郭慧,刘良专,刘江华. 降脂通络软胶囊联合瑞舒伐他汀对2型糖尿病合并高脂血症患者效果观察?[J]. 重庆医学, 2015, 0(24): 3348-3349. DOI: 10.3969/j.issn.1671-8348.2015.24.012 |
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作者姓名: | 郭慧 刘良专 刘江华 |
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作者单位: | 1. 长沙市第八医院内分泌科,长沙,410005;2. 南华大学病原生物学研究所,湖南衡阳,421001;3. 南华大学附属第一医院内分泌科,湖南衡阳,421001 |
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基金项目: | 湖南省衡阳市社会发展科技支撑计划 |
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摘 要: | 目的:观察降脂通络软胶囊联合瑞舒伐他汀治疗2型糖尿病合并高脂血症的临床疗效,并探讨其可能的机制。方法80例2型糖尿病合并高脂血症患者分为联合组与对照组(n=40)。在常规治疗基础上,联合组给予口服瑞舒伐他汀10 mg,1次/天,降脂通络软胶囊100 mg,3次/天口服,对照组予瑞舒伐他汀10 mg,1次/天,口服,连续用药12周。治疗前后分别检测肝功能、肾功能、肌酸激酶,各项血脂指标。结果治疗12周后,联合组在降低血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及超敏 C-反应蛋白(hs-CRP)方面和升高高密度脂蛋白胆固醇(HDL-C)明显优于对照组,差异有统计学意义(P <0.05)。结论瑞舒伐他汀能有效治疗2型糖尿病高脂血症,联合降脂通络软胶囊应用疗效更佳,并且安全性良好。
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关 键 词: | 糖尿病,2 型 高脂血症 降脂通络软胶囊 瑞舒伐他汀 |
Effects of Jiang Zhi Tong Luo Soft Capsule and rosuvastatin on type 2 diabetes combined with hyperlipidemia |
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Abstract: | Objective To observe the effect of combined administration of Jiang Zhi Tong Luo Soft Capsule(JTSC)and rosu-vastatin on type 2 diabetic with hyperlipemia and its possible mechanisms.Methods Eighty cases of Type 2 diabetic patients with hyperlipemia were divided into combine treatment group (40 cases)and control group (40 cases ).On the basis of routine treat-ment,patients in the combine treatment group were treated by oral 10 mg rosuvastatin (once a day)and oral 100 mg JTSC (three times a day ).Patients in control group were treated by oral 10 mg rosuvastatin (once a day and continuously for 12 weeks).We de-tected the liver function,renal functions,creatine kinase,TC,TG,LDL,HDL and hs-CRP were tested before and after treatments. Results After 12 weeks treatment,the combine treatment group was much better than the control group in reducing the level of TG,TC,LDL,hs-CRP and increasing HDL-C(P <0.05 ).Conclusion Rosuvastatin can effectively treat Type 2 diabetic patients with hyperlipemia.Combined administration of JTSC and rosuvastatin shows better effect than rosuvastatin used alone on the treat-ment of Type 2 diabetic patients with hyperlipemia. |
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Keywords: | diabetes mellitus,type2 hyperlipidemia Jiang Zhi Tong Luo Soft Capsule(JTSC) rosuvastatin |
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