超声波辐射下异阿魏酸对氯苯酚酯的一步合成

室温超声辐射下,4-二甲氨基吡啶(DMAP)作催化剂,二环己基碳二亚胺(DCC)作脱水剂,不需保护异阿魏酸分子中的羟基,异阿魏酸和对氯苯酚的一步反应直接合成了异阿魏酸对氯苯酚酯。在n(异阿魏酸):n(对氯苯酚):n(DCC):n(DMAP)=1:1.2:1.2:0.1混合时,室温超声反应2.5h,得产率76.2%。目标化合物的结构经元素分析、1HNMR和IR测试技术得到确证。缩短了反应时间,提高了产率。

One-step Synthesis of 4-Chlorophenyl Isoferulate under Ultrasonic Irradiation

4-Chlorophenyl isoferulate was synthesized in one step from isoferulic acid and 4-chlorophenol without the protection of the hydroxyl of isoferulic acid in the presence of 4-dimethylpyridine(DMAP) as catalyst and dicyclohexylcarbodiimide(DCC) as dehydrating agent under ultrasonic irradiation at room temperature. When reactants were mixed in a n(isoferulic acid)∶n(4-chlorophenol)∶n(DCC)∶n(DMAP)=1∶1.2∶1.2∶0.1, and exposed to ultrasonic irradiation for 2.5 h, the yield was 76.2%. The structure of the product was confirmed by elemental analysis, 1H NMR and IR. This method avoids the long reaction time and increases the yield compared with traditional synthetic method.