丁苯酞治疗一氧化碳迟发性脑病荟萃分析

目的:系统性评价丁苯酞治疗一氧化碳中毒性脑病的疗效.方法:在万方数据-数字化期刊群、中国期刊全文数据库(中国知网)、维普科技期刊数据库、PubMed、EMBase、ClinicalKey数据库中,检索2009年1月至2020年8月的相关研究,探索丁苯酞预防及治疗一氧化碳迟发性脑病的疗效.采用RevMan 5.3软件对各...

Meta analysis of butyphthalide in the treatment of carbon monoxide delayed encephalopathy

Objective:To systematically evaluate the efficacy of butylphthalide in the treatment of carbon monoxide poisoning encephalopathy.Methods:Related studies published from January 2009 to August 2020 were retrived from Wanfang Data-Digitalization Journals,China National Knowledge Infrastructure(CNKI),VIP China Science and Technology Journal Database,PubMed,EMBase and ClinicalKey databases.The efficacy of butylphthalide in the prevention and treatment of carbon monoxide delayed encephalopathy was investigated.The RevMan 5.3 software was used for meta analysis of various effect indexes.Results:A total of 13 studies involving 1140 patients were included in the study.Meta analysis showed that butylphthalide could significantly reduce the incidence of delayed encephalopathy in the patients with carbon monoxide poisoning95%CI(0.10,0.42),P<0.001],improve the mini-mental state examination scores(MMSE)95%CI(2.91,6.02),P<0.001],as well as Barthel indexes95%CI(11.05,13.10),P<0.001]in the patients with carbon monoxide delayed encephalopathy.Conclusion:Butylphthalide could prevent and treat carbon monoxide delayed encephalopathy,and is suitable for clinical application.