| 中试规模制备L-茶氨酸及其衍生物 |
| |
| 引用本文： | 钱绍松,陈然,刘毅,吴晓燕,李加友,焦庆才.中试规模制备L-茶氨酸及其衍生物[J].精细化工,2005,22(11):845-847. |
| |
| 作者姓名： | 钱绍松 陈然 刘毅 吴晓燕 李加友 焦庆才 |
| |
| 作者单位： | 南京大学,生命科学院,医药生物技术国家重点实验室,江苏,南京,210093 |
| |
| 基金项目： | 国家技术创新基金（02CJ-13-01-16）资助 |
| |
| 摘 要： | 报道了中试规模制备L-茶氨酸和L-谷氨酰胺的一种方法。以廉价的L-谷氨酸为原料,采用邻苯二甲酰基作为保护基,保护L-谷氨酸的α-氨基,醋酐回流10 m in使其分子内脱水生成N-邻苯二甲酰-L-谷氨酸酐,在常温、常压条件下,分别与2 mol/L氨水和2 mol/L乙胺水溶液反应生成中间产物N-邻苯二甲酰-L-谷氨酰胺、N-邻苯二甲酰-L-茶氨酸,中间产物在室温条件下与0.5 mol/L水合肼反应48 h脱除保护基,分别以57%、61%的收率得到L-谷氨酰胺和L-茶氨酸。
|
| 关 键 词： | L-茶氨酸 L-谷氨酰胺 L-谷氨酸 N-邻苯二甲酰氨基酸 |
| 文章编号： | 1003-5214（2005）11-0845-03 |
| 收稿时间： | 2005-05-16 |
| 修稿时间： | 2005-05-162005-06-22 |
Synthesis of L-Theanine and Its Derivative on Pilot-plant Scale |
| |
| QIAN Shao-song,CHEN Ran,LIU Yi,WU Xiao-yan,LI Jia-you,JIAO Qing-cai.Synthesis of L-Theanine and Its Derivative on Pilot-plant Scale[J].Fine Chemicals,2005,22(11):845-847. |
| |
| Authors: | QIAN Shao-song CHEN Ran LIU Yi WU Xiao-yan LI Jia-you JIAO Qing-cai |
| |
| Affiliation: | The State Key Laboratory of Pharmaceutic Biotechnology , School of Life Science , Nanjing University , Nanjing 210093 , Jiangsu , China |
| |
| Abstract: | Protected L-glutamic acid was prepared using inexpensive phthaloyl as protecting group. Then N-phthaloyl-L-glutamic acid anhydride was synthesized with protected L-glutamic acid and acetic anhydride under reflux for 10 minutes. Under ambient temperature and pressure, N-phthaloyl-L- theanine and N-phthaloyl-L-glutamine were produced by reaction of N-phthaloyl-L-glutamic acid anhydride with 2 mol/L ethylamine solution and 2 mol/L ammonia solution respectively. Subsequently, the phthaloyl group was removed from the intermediates with 0.5 mol/L hydrazine hydrate under ambient temperature for 48 h. As a result, L-theanine and L-glutamine were obtained in 61% and 57% yields respectively. |
| |
| Keywords: | L-theanine L-glutamine L-glutamic acid N-phthaloyl amino acids |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
