| P16、P53、PCNA在膀胱癌中的表达及意义 |
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| 引用本文： | 居红格,沈淑萍,耿虹,王欣欣. P16、P53、PCNA在膀胱癌中的表达及意义[J]. 包头医学院学报, 2009, 25(6): 12-13 |
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| 作者姓名： | 居红格 沈淑萍 耿虹 王欣欣 |
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| 作者单位： | 包头医学院病理学教研室,内蒙古,包头,014060 |
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| 摘 要： | 目的：研究P16、P53、PCNA在膀胱癌中表达及其意义。方法：应用免疫组化S-P法检查52例膀胱癌组织中P53、P16、PCNA表达水平。结果：52例膀胱移行细胞癌中P16、P53、PCNA阳性表达率分别为42.3%5、7.6%、59.6%,P16阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为58.8%3、8.5%和22.2%,P53阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为41.2%、57.7%和88.9%,PCNA阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为17.3%3、0.8%和66.7%;随着膀胱癌病理分级上升,P16表达阳性率逐渐下降,P53和PCNA阳性率逐渐上升。结论：P16、P53、PCNA的免疫组化检测具有评估膀胱癌预后的价值。
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| 关 键 词： | P16 P53 PCNA 膀胱肿瘤 免疫组织化学 |
The Expression and Significance of P16,P53 and PCNA in Bladder Carcinoma |
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| JU Hongge,SHEN Shuping,GENG Hong,et al. The Expression and Significance of P16,P53 and PCNA in Bladder Carcinoma[J]. Journal of Baotou Medical College, 2009, 25(6): 12-13 |
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| Authors: | JU Hongge SHEN Shuping GENG Hong et al |
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| Affiliation: | JU Hongge,SHEN Shuping,GENG Hong,et al(Department of Pathology,Baotou Medical College,Baotou 014060,China) |
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| Abstract: | Objective： To study the expression and significance of P16,P53 and PCNA in bladder carcinoma.Methods： The immunohisto-chemical staining method was used to evaluate the positivity of P16,P53,PCNA 2 in 52 cases of bladder carcinoma.Results： Of 52 cases,P16 was positive in 22（42.3 %）,P53 was positive in 30（57.6 %）and PCNA positive in 31（59.6 %）.P16 positivity rate in grade I,Ⅱand Ⅲtumors was 58.8 %,38.5 % and 22.2 % respectively;The P53 positivity rate in grade Ⅰ,Ⅱand Ⅲ tumors was 41.2 %,57.7 % and 88.9 %,
respectively; The PCNA positivity rate in grade Ⅰ , Ⅱ and Ⅲ tumors was17.3 % ,30.8 %and 66.7 0% respectively. P16 positivity rate was significantly lower in the patients poorly differentiated, but P53 and PCNA positivity rate was significantly higher in the patients poorly differentiated. Conclusion： Immunohisto--chemecal analysis of P16, P53 and PCNA is of some value in evaluating prognosis of bladder cancer. |
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| Keywords: | P16 P53 PCNA |
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