| 3，4-二氢吡咯[2，1-c][1，4]噘嗪-1-酮及其7-芳酰基衍生物的设计与合成 |
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| 引用本文： | 魏玮,KHAN,Ali,Yousaf,郭永恩,石乐君.3，4-二氢吡咯[2，1-c][1，4]噘嗪-1-酮及其7-芳酰基衍生物的设计与合成[J].天津轻工业学院学报,2009(4):1-5. |
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| 作者姓名： | 魏玮 KHAN Ali Yousaf 郭永恩 石乐君 |
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| 作者单位： | 工业微生物教育部重点实验室,天津科技大学生物工程学院,天津300457 |
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| 基金项目： | 天津科技大学引进人才科研启动基金资助项目（20060405） |
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| 摘 要： | 以2-吡咯基三氯乙酮为主要原料，经过乙二醇单酯化、羟基氯取代、环合三步反应制得了3，4-二氢吡咯2，1-c]1，4]噁嗪-1-酮；又经过Friedel—Crafts酰基化和环合反应制得了未见文献报道的7-芳酰基-3，4-二氢吡咯2，1-c]1，4]噁嗪-1-酮它们及其某些重要中间体的结构分别采用红外光谱、质谱、核磁共振氢谱、核磁共振碳谱以及高分辨率质谱进行了表征．
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| 关 键 词： | 3 4-二氢吡咯 噁嗪-1-酮 合成 Friedel-Crafts酰基化 结构表征 |
Design and Synthesis of 3,4-Dihydropyrrolo[2, 1-c][1,4]oxazin-l-one and Its 7-Acyl Derivatives |
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| WEI Wei,KHAN Ali Yousaf,GUO Yong-en,SHI Le-jun.Design and Synthesis of 3,4-Dihydropyrrolo[2, 1-c][1,4]oxazin-l-one and Its 7-Acyl Derivatives[J].Journal of Tianjin University of Light Industry,2009(4):1-5. |
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| Authors: | WEI Wei KHAN Ali Yousaf GUO Yong-en SHI Le-jun |
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| Affiliation: | (Key Laboratory of Industrial Microbiology ,Ministry of Education, College of Biotechnology,Tianjin University of Science ＆ Technology,Yianjin 300457 ,China) |
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| Abstract: | 3,4-Dihydropyrrolo2,1-c]1,4]oxazin-l-one is prepared with 2-pyrrolyltrichloro-acetone as the major starting material, successively by its monoesterification with ethylene glycol, chlorine displacement of hydroxy group, and cyclization. Unreported two 7-aroyl-3,4-dihydro-pyrrolo2, 1-c]1,4]oxazin-1-one compounds are also synthesized in turn by Friedel-Crafts acylation and cyclization from 2-trichloroacetyl pyrrole. Their structures are characterized by IR,MS, ^1H NMR, 13C NMR and HRMS. |
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| Keywords: | 3 4-dihydropyrrolo oxazin-l-one synthesis Friedel-Craftsacylation structure characterization |
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