血管性认知功能损害患者基于体素的全脑分数各向异性比较

目的 利用扩散张量成像研究血管性认知功能损害(VCI)患者基于体素的全脑范围内白质异常.方法 对19名血管性认知功能障碍患者和19名正常老年人进行扩散张量成像扫描,经过后处理生成分数各向异性(FA)图,在SPM2下进行头颅标准化后,对VCI组和对照组的全脑FA图进行基于体素的统计学t检验.结果 对照组和VCI组的额叶白质、外囊、扣带、颞叶白质、顶叶白质、岛叶的FA值差异具有显著性意义,而且大多以左侧为主.结论 基于体素的全脑白质FA比较能够发现VCI患者中大脑特定部位白质的异常,从而更加客观、全面地评价VCI患者的脑部改变.

Comparison of whole brain fractional anisotropy of patients with vascular cognitive impairment by voxel-based analysis

Objective To detect white matter abnormalities of whole brain fractional anisotropy(FA)in patients with vas- cular cognitive impairment(VCI)by voxel-based analysis in diffusion tensor imaging.Methods Nineteen patients with vas- cular cognitive impairment and nineteen normal aged people underwent diffusion tensor imaging scanning.For every subject, FA map was generated and normalized using SPM2,and t-tests were conducted to compare FA values voxel to voxel between the two groups.Results Significant reductions in FA were found in the white matter in frontal lobe,extra-nuclear,cingu- late,temporal lobe,parietal lobe and insula lobe,especially left side in patients of VCI.Conclusion Comparison of whole brain anisotropy reveals significant decreased FA of multiple fiber tracts in vascular cognitive impairment.This method is valuable to evaluate the microstructural changes thoroughly and objectively.