Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii |
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Authors: | Nanette R Boyle and John A Morgan |
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Affiliation: | (1) School of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, Indiana, 47907, USA |
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Abstract: | Background Photosynthetic organisms convert atmospheric carbon dioxide into numerous metabolites along the pathways to make new biomass.
Aquatic photosynthetic organisms, which fix almost half of global inorganic carbon, have great potential: as a carbon dioxide
fixation method, for the economical production of chemicals, or as a source for lipids and starch which can then be converted
to biofuels. To harness this potential through metabolic engineering and to maximize production, a more thorough understanding
of photosynthetic metabolism must first be achieved. A model algal species, C. reinhardtii, was chosen and the metabolic network reconstructed. Intracellular fluxes were then calculated using flux balance analysis
(FBA). |
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Keywords: | |
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