多不饱和脂肪酸的研究进展

多不饱和脂肪酸(PUFAs)作为一种独特的生物活性物质,对人体有重要的生理功能,ω-3和ω-6多不饱和脂肪酸都是合成类二十烷酸化合物的前体,它们在体内的平衡对于稳定细胞膜功能、调控基因表达、维持细胞因子和脂蛋白平衡、抗心血管病、促进生长发育等方面起着重要作用,是目前营养生化研究热点之一。随着PUFAs开发应用领域的扩大,纯PUFAs脂质的需求量越来越多,近年来人们一直在探索利用PUFAs的新来源——即利用微生物技术来生产PUFAs。介绍了PUFAs的生理作用和来源的研究进展,着重阐述了ω-3和ω-6多不饱和脂肪酸体内代谢、生理功能、ω-3和ω-6多不饱和脂肪酸比例、生物发酵等方面的研究情况。

Research progress in polyunsaturated fatty acids

Polyunsaturated fatty acids(PUFAs)is a unique bioactive substances,it has important physiological function to human body.ω-3 and ω-6 polyunsaturated fatty acids are precursor of eicosanoids synthesis.Their homeostasis plays an important role in stable membrane function,regulation of gene expression,maintaining cell factors and lipoprotein balance,fighting cardiovascular diseases,and promotion of growth.And now it is one of the hotspots of nutrition biochemical.As the expansion of PUFAs application fields,more and more pure PUFAs lipids are needed.In recent years,people have been exploring new sources of PUFAs,namely using microorganism techniques to produce PUFAs.The research progress of PUFAs physiological functions and sources,and emphatically expounds ω-3 and ω-6 polyunsaturated fatty acid metabolism,physiological functions,the scale of ω-3 and ω-6 polyunsaturated fatty acids,fermentation,etc were introduced.