4种甲氧基丙烯酸酯类杀菌剂不同剂型对斑马鱼急性毒性效应

采用半静态法测定了4种甲氧基丙烯酸酯类杀菌剂原药及制剂对斑马鱼(Brachydonio rerio)急性毒性。结果表明,以实测浓度计,250 g·L~(-1)嘧菌酯悬浮剂对斑马鱼的96 h半数致死浓度(LC50)值为0.539 mg·L~(-1),急性毒性为高毒,95%嘧菌酯原药和50%嘧菌酯水分散粒剂对斑马鱼的LC50(96 h)值分别为1.09和1.21 mg·L~(-1),急性毒性均为中毒;98%啶氧菌酯原药和22.5%的啶氧菌酯悬浮剂对斑马鱼的LC50(96 h)值分别为0.0974和0.0972 mg·L~(-1),急性毒性均为剧毒;95%吡唑醚菌酯原药、15%吡唑醚菌酯悬浮剂和250 g·L~(-1)吡唑醚菌酯乳油对斑马鱼的LC50(96 h)值为0.0613、0.0549和0.0487 mg·L~(-1),急性毒性均为剧毒;95%醚菌酯原药和50%醚菌酯水分散粒剂对斑马鱼的LC50(96 h)值分别为0.468和0.702 mg·L~(-1),急性毒性均为高毒。这4种甲氧基丙烯酸酯类杀菌剂对斑马鱼均有较高风险,会对其他水生生物也存在潜在的风险。

Acute Toxicity of Different Formulation of Four Strobilurin Fungicides to the Zebrafish (Brachydonio rerio)

Acute toxicity of different formulation of four strobilurin fungicides to zebrafish (Brachydonio rerio) was detected with the semi-static method. Based on measured concentrations, results showed that 250 g?L^-1 azoxystrobin suspension concentrate (SC) is very toxic to zebrafish with an LC₅₀ (96 h) value of 0.539 mg?L^-1. In contrast, 95% azoxystrobin technical material (TC) and 50% azoxystrobin water dispersible granule (WG) were moderately toxic to zebrafish with LC₅₀ (96 h) values of 1.09 and 1.21 mg?L^-1, respectively. Both 98% picoxystrobin TC and 22.5% picoxystrobin SC were extremely toxic to zebrafish with LC₅₀ (96 h) values of 0.0974 and 0.0972 mg?L^-1. All test fungicides pyraclostrobin were also extremely toxic to zebrafish with the relative toxicity (LC₅₀) in decreasing order as follows: 95% pyraclostrobin TC (0.0613 mg?L^-1)> 15% pyraclostrobin SC (0.0549 mg?L^-1)>250 g?L^-1 pyraclostrobin emulsifiable concentrates (EC) (0.0487 mg?L^-1). 95% kresoxim-methyl TC and 50% kresoxim-methyl WG were very toxic to zebrafish, and their LC₅₀ (96 h) values were 0.468 and 0.702 mg?L^-1, respectively. These results suggested that all tested strobilurin fungicides have the potential risk to zebrafish and the other aquatic organisms.