Signal-to-noise ratio improvements in in vivo high resolution micro-volume selected spectroscopy |
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| Authors: | S Crozier J Field D M Doddrell |
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| Affiliation: | Department of Chemistry, University of Queensland, St. Lucia, Australia. |
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| Abstract: | A system capable of in vivo volume selected 1H NMR spectroscopy of voxels as small as 0.2 cm3 is described. Signal-to-noise ratio improvements with probe design and a novel signal steering device are detailed. A high-resolution, image-directed proton spectrum from 0.2 cm3 of a rat's brain at 200 MHz obtained using the SUBMERGE/SPACE pulse sequence is presented. Single-scan voxel shimming was implemented to improve spectral resolution. |
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