| 煎煮时间对附子水煎液总生物碱和6种酯型生物碱含量的影响 |
| |
| 引用本文： | 匡青芬,;侯大斌,;孙鸿,;岳聪慧.煎煮时间对附子水煎液总生物碱和6种酯型生物碱含量的影响[J].辽宁中医杂志,2014(8):1707-1710. |
| |
| 作者姓名： | 匡青芬 ;侯大斌 ;孙鸿 ;岳聪慧 |
| |
| 作者单位： | [1]西南科技大学生命科学与工程学院,四川绵阳621010; [2]四川江油中坝附子科技发展有限公司,四川江油621700 |
| |
| 基金项目： | 国家“十二五”科技支撑计划课题（2011BAI13B05）; 四川省“十二五”农作物育种攻关课题（2011NZ0098-12） |
| |
| 摘 要： | 目的:研究煎煮时间对附子水煎液总生物碱和6种酯型生物碱含量的影响。方法:采用酸碱滴定法测定总生物碱含量;采用HPLC,Agilent ZORBAX Extend-C18分析柱测定6种酯型生物碱含量。结果:随着煎煮时间的延长,不同炮制品中总生物碱的溶出率变化不明显;不同炮制品煎煮过程中酯型生物碱的变化规律不尽相同,其中乌头碱(AC)含量最低,水解最为彻底。结论:临床大剂量应用附子时,最大限度发挥其药理作用,恰如其分地掌握剂量与煎煮时间,是必不可少的。
|
| 关 键 词： | 煎煮 生物碱 附子 |
Effect of Different Decocting Time on Contents of Ester - type Alkaloids in Water Decoction of Aconitum carmichaeli Dexb |
| |
| Affiliation: | KUANG Qingfen ,HOU Dabin ,SUN Hong ,YUE Conghui ( 1. College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China ; 2. Sichuan Jiangyou Zhongba Aconiti Lateralis Radix Technology Development Company, Jiangyou 621700, Sichuan, China) |
| |
| Abstract: | Objective： To study the effect on total alkaloids and six kinds of ester - type alkaloids in water decoction of Aconitum carmichaeli Dexb. by different decocting time. Methods ： The contents of total alkaloids were measured by acid base titration; the six kinds of ester - type alkaloids were tested by HPLC with Agilent ZORBAX Extend - C18. Results ：As the extension of decoction time, the change of dissolution rate of total alkaloid in different processed drugs was not obvious. With the different processed drugs, the change law of ester type alkaloid in the process of the decoction was not the same ; the content of alkaloid was the lowest;the hydrolysis of alkaloid was most completely. Conclusion：It＇s essential to play maximum of pharmacological action and master dose and decoction time appropriately when apply of aconitum carmichaeli in clinic in a high - dose. |
| |
| Keywords: | decoction alkaloids Aconitum carmichaeli Dexb |
| 本文献已被 维普 等数据库收录！ |
|
