不同性别2型糖尿病患者血清γ-谷氨酰转肽酶水平与代谢综合征的相关性研究

目的探讨江苏省成人2型糖尿病（T2DM）患者血清γ-谷氨酰转肽酶（GGT）与代谢综合征（MS）组分的相关性。方法测定T2DM患者（男438例，女300例）的GGT、血脂、空腹血糖（FBG）、空腹胰岛素（FINS）、血压、腰围等。结果①随着GGT四分位数的升高，男、女2组的体质量指数（BMI）、三酰甘油（TG）、FINS及稳态胰岛素评估模型胰岛素抵抗（HOMA—IR）指数升高；②男性组的GGT与腰围、BMI、舒张压（DBP）、TG、总胆固醇（TC）、FINS及MS组分数呈正相关，女性组的GGT与TG呈正相关（P均〈0．01）；③男、女性组GGT与HOMA—IR呈正相关（P均〈0．05）；④线性回归模型的结果显示，男性组中GGT水平主要受腰围及TG水平的影响，女性组中GGT水平主要受TG水平的影响。结论T2DM患者血清GGT与胰岛素抵抗及MS组分相关，同时在MS各组分中，GGT与TG水平最具相关性，提示GGT可能与肝脏胰岛素抵抗密切相关。

Association of serum gamma-glutamyltransferase with metabolic syndrome in different genders with type 2 diabetes mellitus

Objective To explore the association between serum gamma glutamyltransferase(GGT) and the components of metabolic syndrome in patients with type 2 diabetes mellitus of Jiangsu Province. Methods A total of 738 patients with type 2 diabetes(men 438 and women 300)were selected.The levels of serum GGT,lipid,fasting plasma glucose(FBG),fasting insulin(FINS),blood pressure and waist were measured. Results ①As the quartile of serum GGT increased,BMI,TG,FINS and HOMA-IR were increased in both genders;②Serum GGT was positively correlated with waist,BMI,DBP,TG,TC,FINS and the numbers of components of MS in men(P<0.01),and was positively correlated with TG in women(P<0.01),and serum GGT had the highest correlation with TG;③Serum GGT was positively correlated with HOMA-IR(r=0.281 in men and r=0.230 in women,P<0.05);④In linear regression model,serum GGT was mainly influenced by waist and TG in men and TG in women,respectively. Conclusions Serum GGT is closely related with insulin resistance and the components of MS.Among the components of MS,serum GGT had the highest correlation with TG,suggesting that serum GGT may have close association with hepatic insulin resistance.