甲基黄酮醇胺对大鼠和小鼠记忆障碍的改善作用

采用被动回避反应障碍动物模型，观察甲基黄酮醇胺（ＭＦＡ）对学习记忆的改善作用．结果，一次ｉｐＭＦＡ１０－２０ｍｇ·ｋｇ－１能明显对抗最大电休克致大鼠空间记忆损害．缩短其水迷宫实验中寻找水下平台时间，增加跨越水下平台相应位置的次数．在小鼠跳台实验中，ｉｐＭＦＡ５－１０ｍｇ·ｋｇ－１，每日１次，连续５ｄ，能逆转东莨菪碱（２ｍｇ·ｋｇ－１）所致记忆获得不良，改善亚硝酸钠（１２０ｍｇ·ｋｇ－１）引起的记忆巩固障碍及４０％乙醇（１０ｍＬ·ｋｇ－１）所致记忆再现障碍．延长小鼠台上停留时间，缩短电击后逃避潜伏期．同时，ｉｐＭＦＡ１０ｍｇ·ｋｇ－１，对小鼠的自主活动及痛阈无明显影响．提示，ＭＦＡ对电击和不同化学药品所致学习记忆损伤均具有显著改善作用

Improving effect of methylflavonolamine on memory dysfunction in mice and rats

The improving effect of methyl- flavonolamine (MFA) on the memory dysfunction was studied using animal models of the passive avoidance reactive disorders in mice and rats. The results showed that a single dose of MFA 10-20 mg·kg^-1 ip improved the spatial memory dysfunction induced by maximal electroconvulsive shock (MECS) in rats. It shortened the latency of searching platform beneath the water and increased the number of swimming across the area where the platform had been located on previous trials in the experiment of water maze. In mouse step-down test, MFA, 5-10 mg·kg^-1 ip once a day for 5 d, alleviated the memory impairments of acquisition,retention and retrieval induced by scopolamine (2 mg·kg^-1), sodium nitrite (120 mg·kg^-1) and 40% ethanol (10 mL·kg^-1), respectively, prolonging the step- down latency and shortening the escape latency after electric stimulation. At the same time, no significant effects on the spontaneous motor activity and the pain threshold were observed. The results indicate that MFA can improve memory dysfunction induced by MECS and various chemical agents.