平原人进驻高原后红细胞生成素的变化

目的　探讨红细胞生成素在高原低氧适应机制中的作用。方法　对平原进驻海拔 3 70 0m和气 5 3 80m第 7天及半年的健康青年进行血液促红细胞生成素 (EPO)、血红蛋白 (Hb)及血氧饱和度 (SaO2 )检测 ,并与平原健康青年作对照。结果　进驻高原低氧环境EPO、Hb较平原增高显著 (P <0 .0 5或 0 .0 1 ) ,SaO2 降低非常显著 (P <0 .0 1 )。进驻高原第 7天和半年 ,3 70 0m较 5 3 80mEPO ,Hb降低非常显著 ,SaO2 增高非常显著 (P <0 .0 1 )。进驻 3 70 0m ,第 7天较半年EPO无统计学意义 (P >0 .0 5 ) ,Hb ,SaO2 差异显著 (P <0 .0 5或 0 .0 1 ) ;进驻 5 3 80m ,第 7天较半年EPO ,Hb,SaO2 均有显著性差异 (P <0 .0 5或P <0 .0 1 )。结论　在高原缺氧环境下 ,红细胞生成素调节机制紊乱 ,是导致继发性红细胞增多的一个重要环节。

Change of Erythropoietin on High Altitude Hypoxia Adaptation Mechanism

Objective To study the change of erythropoietin (EPO) under high altitude hypoxia circumstance. Methods To determine their EPO, hemoglobin (Hb) and blood oxygen saturation (SaO 2) when the 40 subjects entered high altitude (3 700 m, 5 380 m) from plain (1 400 m) at the 7 th day and for months, and compared with 20 subjects who had stayed in the plain. Results Under the high altitude hypoxia circumstance, EPO and Hb were much higher than that of plain (P<0.01), but SaO 2 is decrease notable (P<0.01), the higher you enter, the higher countent of EPO and Hb you will take, but the lower SaO 2 is (P<0.01), and the longer staytime is, the higher countent of SaO 2 and Hb, the lower countent of EPO (P<0.05 or P<0.01). Conclusion Under the high altitude hypoxia, the regulate mechanism of EPO is disorder, and maybe it is the important link which lead to the secondary erythrocythemia.