88株耐异烟肼分支杆菌耐药模式分析

目的为了探讨近年来耐异烟肼分支杆菌同时耐其他几种抗结核药物的耐药模式提供防治结核病参考。方法采用绝对浓度法对临床分离的181株分支杆菌进行10种药物敏感性试验。结果初始耐药率为19．3％，获得性耐药为55．8％，耐异烟肼及其以上分支杆菌占耐药菌株的37．6％。88株耐异烟肼分支杆菌中耐3种及其以上药物的分支杆菌占85．2％。结论耐异烟肼分支杆菌多数是多重耐菌株，在结核病防治工作中应高度重视，以控制或降低初始和获得性耐药的高耐率。

Analysis on resistance pattern of 88 strains of isoniazid-resistant Mycobacteria

Objective To explore the multi-resistance pattern of 88 strains of isoniazid-resistant Mycobacteria in recent years,so as to provide reference for prevention and treatment of tuberculosis.Methods Absolute concentration method was applied to performing drug susceptibility test for 181 isolates of Mycobacteria to 10 kinds of antitubercuIosis drugs. Results The primary resistance rate was 19.3%,and the acquired drug resistance rate Was 55.8%.The percentage of isoniazid-or double resistant-Mycobacteria was 37.6%.The Mycobacterium which was resistant to three or above drugs accounted for 85.2 %.Conclusion The majority of isoniazid-resistant Mycobacterium is a multi-resistant strain,which should be thought highly in prevention and treatment of tuberculosis to control or reduce the initial and acquired resistance rates.