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| 灵五颗粒对刀豆蛋白A所致小鼠免疫肝损伤的保护作用 | |
| 引用本文： | 徐雪钰,刘军,于珊,胡克章,刘青川,程丽娟,黄正明.灵五颗粒对刀豆蛋白A所致小鼠免疫肝损伤的保护作用[J].解放军药学学报,2011,27(2):113-117. |
| 作者姓名： | 徐雪钰 刘军 于珊 胡克章 刘青川 程丽娟 黄正明 |
| 作者单位： | 1. 100091 北京,解放军309医院药剂科;100039 北京,解放军302医院药学部 2. 解放军302医院药学部, 北京,100039 3. 解放军309医院药剂科, 北京,100091 4. 第一人民医院药剂科, 四川内江,641000 |
| 摘 要： | 目的 观察灵五颗粒对刀豆蛋白A所致小鼠免疫性肝损伤的保护作用.方法 采用尾静脉注射刀豆蛋白A致小鼠肝损伤模型.60只小鼠随机分为正常组、刀豆蛋白A模型组、灵五颗粒低、中、高(2.5,5,10g/kg)剂量组和阳性药联苯双酯(0.15 g/kg)组.各组动物连续灌胃给药5,7 d后,尾静脉注射刀豆蛋白A(20mg/kg)... |
| 关 键 词： | 灵五颗粒 刀豆蛋白A 肝损伤 保肝作用 |
Protective Effects of Lingwu Granula on Immunological Liver Injury Induced by Concanavalin A in Mice |
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| XU Xue-yu,LIU Jun,YU Shan,HU Ke-zhang,LIU Qing-chuan,CHENG Li-juan,HUANG Zheng-ming.Protective Effects of Lingwu Granula on Immunological Liver Injury Induced by Concanavalin A in Mice[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(2):113-117. | |
| Authors: | XU Xue-yu LIU Jun YU Shan HU Ke-zhang LIU Qing-chuan CHENG Li-juan HUANG Zheng-ming |
| Affiliation: | 1.Department of Pharmacy, Hospital 309 of PLA, Beijing 100091,China ;2.Department of Pharmacy,Hospital 302 of PLA, Beijing 100039, China ;3.Department of Pharmacy, The First People＇s Hospital of, Neijiang 641000, China) |
| Abstract: | Objective To study the protective effect of Lingwu Granula on immunological liver injury induced by concanavalin A in mice.Methods A model of immunological liver injury was induced by concanavalin A in mice.60 mice were randomly divided into six groups: normal,model,Lingwu Granula treatment low,medium,high(2.5,5,10 g/kg) and bifendate group(0.15 g/kg).After intragastric administration of corresponding drugs for 5 and 7 consecutive days,mice were injected by vena caudalis with concanavalin A(20 mg/kg).The ac... |
| Keywords: | Lingwu Granula concanavalin A liver injury hepatoprotection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
