| 胶质细胞瘤复发前后Cyclin D1和P16的表达 |
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| 引用本文： | 王伟,唐晓平,张跃康,毛伯镛,步宏.胶质细胞瘤复发前后Cyclin D1和P16的表达[J].中国神经精神疾病杂志,2003,29(2):104-106. |
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| 作者姓名： | 王伟 唐晓平 张跃康 毛伯镛 步宏 |
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| 作者单位： | 1. 四川大学华西医院,成都,610041
2. 川北医学院附属医院 |
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| 摘 要： | 目的 探讨CyclinD1,P16在胶质瘤复发前后表达改变及其意义。方法 采用免疫组织化学LsABC法对 4 5例复发胶质瘤瘤组织、瘤旁脑组织和 10例正常脑组织CyclinD1,P16蛋白表达进行检测 ,统计分析CyclinD1,P16表达水平与胶质瘤分级、肿瘤复发的关系。结果 正常脑组织 ,瘤旁脑组织和胶质瘤组织CyclinD1表达依次升高 ,而P16的表达依次下降 ;肿瘤复发CyclinD1表达增强 ,P16的表达减弱。结论 CyclinD1与P16的表达与胶质瘤恶性进程和复发密切相关。
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| 关 键 词： | CyclinD1 P16 胶质瘤 复发 |
| 修稿时间： | 2002年5月26日 |
Expression and significance of Cyclin D1 and P16 protein in recurrent human glioma |
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| Wang Wei,Tang Xiaoping,Zhang Yuekang,Mao Boyong,Bu Hong. West China Hospital of Sichuan University, Guo Xui Road,Chengdu. ..Expression and significance of Cyclin D1 and P16 protein in recurrent human glioma[J].Chinese Journal of Nervous and Mental Diseases,2003,29(2):104-106. |
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| Authors: | Wang Wei Tang Xiaoping Zhang Yuekang Mao Boyong Bu Hong West China Hospital of Sichuan University Guo Xui Road Chengdu [ |
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| Affiliation: | Wang Wei,Tang Xiaoping,Zhang Yuekang,Mao Boyong,Bu Hong. West China Hospital of Sichuan University,37 Guo Xui Road,Chengdu. 610041.[ |
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| Abstract: | Objective To investigate the expression alteration of Cyclin?D1 and P16 in recurrent glioma and its relationship with histopathological degree of malignancy of glioma. Methods Cyclin?D1/P16 expression of 10 normal brain tissue, 45 brain tissue samples adjacent to tumor and glioma tissue were studied by immunohistochemical staining. Results The expression level of cyclin?D1 incresed in the ascending order from normal brain tissue, to brain tissue samples adjacent to tumor, and finally to glioma itself. The expression of P16 showed opposite results with decreasing expression in these tissues. Cyclin?D1 expression was higher and P16 expression lower in relapsed tumor. Conclusions The results suggest that Cyclin?D1 and P16 play an important role in the carcinogensis and recurrence of glioma. |
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| Keywords: | Cyclin?D1 P16 Glioma Recurrence |
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