济南市居民高尿酸血症及影响因素分析

目的 调查济南市35~64岁人群高尿酸血症患病率并对其相关因素进行分析。方法 对4041例健康查体人群进行横断面调查,应用Logistic回归模型分析影响因素与高尿酸血症的相关性。结果 男性高尿酸血症患病人数为126例,患病率为6.4%;女性44例,患病率为2.1%。Logistic多元回归模型显示,高甘油三酯血症(OR=6.155)、高胆固醇血症(OR=2.853)、男性(OR=2.749)、高血压(OR=1.884)、腹型肥胖(OR=1.834)与高尿酸血症升高相关;农村人群(OR=0.266)、饮酒者(OR=0.807)则与高尿酸血症降低相关。结论 济南市人群高尿酸血症发病率较低;高甘油三酯血症、高胆固醇血症、男性、高血压、腹型肥胖可能为高尿酸血症的危险因素;农村、适量饮酒可能为保护因素。

Analysis on hyperuricemia and its influential factors in population

Objective To investigate the prevalence of hyperuricemia and its risk factors in the general adult population aged 35～64 years in Jinan.Methods To analyze data on 4 041 residents aged 35～64 years from the cross-sectional survey of Jinan.Physical examination was carried out and fasting blood was tested.Data were analyzed by multivariate Logistic regression models.Results 1 979 men and 2 062 women participanted in the study 16.4% of men and 2.1% of women had hyperuricemia,which was defined as serum uric acid≥417μmol/L in men and≥357μmol/L in women.Multivariate Logistic regression models found thathypertriglyceridemia(OR 6.155,95%CI 4.354～8.701),hypercholesteremia(OR 2.853,95%CI 1.796～4.531),male gender(OR 2.749,95%CI 1.781～4.245),hypertension(OR 1.884,95%CI 1.320～ 2.687),central obesity(OR 1.834,95%CI 1.209～2.781)were associated with increased risk of hyperuricemia,however,living in rural areas(OR 0.266,95%CI 0.177～0.398)and alcohol consumption(OR 0.807,95%CI 0.706～0.892)were associated with reduced risk of hyperuricemia.Conclusion Hypertriglyceridemia,hypercholesteremia,male gender,hypertension,central obesity are associated with increased risk of hyperuricemia.Alcohol consumption and living in rural areas are associated with reduced risk of hyperuricemia.