GENETIC POLYMORPHISM IN HUMAN β-DEFENSIN-1 AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN HAN POPULATION IN SOUTH OF CHINA |
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| Authors: | ZHOU Min HUANG Shao-guang WAN Huan-ying LI Min RONG Xia-jun LI Biao |
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| Affiliation: | ZHOU Min(Department of Pulmonary Medicine, RuiJin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China)；HUANG Shao-guang(Department of Pulmonary Medicine, RuiJin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China)；WAN Huan-ying(Department of Pulmonary Medicine, RuiJin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China)；LI Min(Department of Pulmonary Medicine, RuiJin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China)；RONG Xia-jun(Department of Pulmonary Medicine, RuiJin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China)；LI Biao(Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China)； |
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| Abstract: | Objective To investigate the correlation between human β-defensin-1 ( HBD-1) exon 2 variations and chronic obstructive pulmonary disease susceptibility in Han population in south of China. Methods The frequency of polymorphic genotypes of HBD-1 exon 2 (1654G/A) was examined in 120 COPD patients ( COPD group) and 108 smokers without COPD ( control group) by restriction fragment length polymorphism. Results The frequencies of polymorphic genotypes in HBD-1 exon 2 in COPD group were G/G 82.50%, G/A 10. 83%, and A/A 6. 67%. The frequencies of polymorphic genotypes in control group were G/G 95.37%, G/A 3. 70%, and A/A 0. 93 %. It showed significant difference between two groups ( P ＜ 0. 01 ). The differences in allele frequencies were also significant between two groups ( G allele frequency: 87. 92% vs 97. 22%; A allele frequency: 12. 08% vs 2.78%; P ＜ 0. 01 ). The G→A mutation rised along with the severity of the COPD. Conclusion The genetic polymorphism in HBD-1 exon 2 gene might be associated with the susceptibility to COPD in Han population of South China. |
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