TS、TP在胃癌中表达及与预后的关系

目的 检测胸苷酸合成酶（TS）、胸苷磷酸化酶（TP）在胃癌中的表达,分析其与胃癌临床病理因素、复发转移及预后的关系.方法 采用免疫组化SP法检测TS和TP在77例胃癌组织和25例癌旁正常组织中的表达.结果 ①TS和TP在胃癌组织中的阳性表达率分别为70.1%及59.7%,显著高于癌旁正常组织的阳性表达率24.0%及12.0%,差异均有统计学意义（P＜0.05）.②TS在胃癌组织中的表达与淋巴结转移有关（P＜0.05）,而与其他临床病理特征无关;TP在胃癌组织中的表达与胃癌分化程度、浸润深度、淋巴结转移及胃癌分期间差异均有统计学意义（P＜0.05）.③TS和TP在胃癌根治术后5年内发生复发转移者的阳性表达率分别为78.6%和78.6%,显著高于未复发转移组的阳性表达率,差异均有统计学意义﹙P＜0.05）.④Kaplan-Meier生存分析结果表明,TS、TP阴性表达者较之阳性表达者生存期明显延长（P＜0.05）.结论 胃癌组织中存在TS、TP的高表达,其表达与胃癌复发转移及预后呈负相关,可作为预测侵袭转移及评估预后的分子生物学标志物.

The expressions of TS and TP in gastric cancer and its relationship with prognosis

Objective To detect the expression of TS and TP in gastric cancer, and to analyze the relations between them with recurrence, metastasis and prognosis of gastric cancer. Methods The expressions of TS and TP were studied by immunohistochemical SP in 107 cases of gastric cancer and in 25 cases of neighboring gastric cancer tissue. Results The rate of positive expression of TS and TP in gastric cancer tissue were respectively 70.13% and 59.74% , it was significantly higher than those in neighboring gastric cancer tissue which was 24.0% and 12.0%, respectively. All of the differences have statistically significant （all of P 〈0.05） ;TS expression was associated with lymph node metastasis in the tissue of gastric cancer （ P 〈 0.05 ） and has nothing to do with the other clinical patho logical factors;The expression of TP in gastric cancer with the differentiation degree, infiltration depth, lymph node metastasis and gastric cancer points during the differences were statistically significant （ P 〈 0.05 ） ;The rate of positive expression of TS and TP in patients who had recurrence metastasis after curative operation within 5 years, were respectively 78.57% and 78.57% , which were obviously higher than those in non - recurrence metastasis groups positive expression. The difference had statistically significant （ P 〈 0.05 ） ; The result of Kaplan - Meier survival analysis shows ： the 5 years＇ survival rates of patients who had negative expression of TS and TP were obviously higher than those who had positive expression （ P 〈 0.05 ）. Conclusion The expressions of TS and TP are closely correlated to the re currence metastasis and prognosis of gastric cancer, all of them could be the molecular markers for both predicting invasion metastasis and assessing prognosis.