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| 实验性变态反应性脑脊髓炎大鼠星形胶质细胞的变化 | |
| 引用本文： | 李勇,郑荣远,王小同,李剑敏,邵蓓,潘建春,杨学志.实验性变态反应性脑脊髓炎大鼠星形胶质细胞的变化[J].中风与神经疾病杂志,2005,22(3):233-234,i002. |
| 作者姓名： | 李勇 郑荣远 王小同 李剑敏 邵蓓 潘建春 杨学志 |
| 作者单位： | 1. 温州医学院第二附属医院神经内科,浙江,温州,325000 2. 温州医学院第一附属医院神经内科,浙江,温州,325000 3. 温州医学院第一附属医院病理科,浙江,温州,325000 4. 温州医学院药理学院,浙江,温州,325000 |
| 基金项目： | 浙江省重点学科基金资助项目(XXf99005) |
| 摘 要： | 目的观察实验性变态反应性脑脊髓炎(EAE)大鼠脊髓中星形胶质细胞的变化,探讨EAE大鼠的发病相关生物学机制。方法采用免疫组化法,对豚鼠全脊髓匀浆诱导的Wistar大鼠EAE的过程中,脊髓内星形胶质细胞变化情况进行研究。结果EAE大鼠症状高峰期时星形胶质细胞开始激活,恢复期时激活达到高峰,而且活化的星形胶质细胞未见表达主要组织相容性抗原(MHC)。结论活化的星形胶质细胞可能与EAE大鼠的恢复有关。 |
| 关 键 词： | 实验性变态反应性脑脊髓炎 星形胶质细胞 主要组织相容性抗原 |
| 文章编号： | 1003-2754(2005)03-0233-02 |
The change of astrocyte in experimental allergic encephalomyelitis in rats |
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| LI Yong,ZHENG Rong-yuan,WANG Xiao-tong,et al..The change of astrocyte in experimental allergic encephalomyelitis in rats[J].Journal of Apoplexy and Nervous Diseases,2005,22(3):233-234,i002. | |
| Authors: | LI Yong ZHENG Rong-yuan WANG Xiao-tong |
| Abstract: | Objective To observe the change of astrocyte in cords and explore the mechanism of EAE in rat. Methods The experimental allergic encephalomyelitis (EAE) was induced by guinea pig spinal cord homogenate (GPSCH) and the expression of glial fibrillary acidic protein (GFAP) in cords was examined using polyclonal antibody to GFAP at various stages with the method of immunohistochemistry. Results At the peak stage of EAE in rats,the astrocytes began to be activated. At the recovery stage of EAE,the astrocytes were significantly activated. Moreover the activated astrocytes did not express major histocompatibility complex (MHC) antigen. Conclusion There is relationship between activated astrocytes and recovery of EAE. |
| Keywords: | Experimental allergic encephalomyelitis Astrocytes Major histocompatibility complex |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
