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| 实验性脑血管痉挛时一氧化氮与超氧化物歧化酶对脑血流的作用研究 | |
| 引用本文： | 滕伟禹,邹仁林,曹云鹏,吴哲,汤浩. 实验性脑血管痉挛时一氧化氮与超氧化物歧化酶对脑血流的作用研究[J]. 中风与神经疾病杂志, 2000, 17(5): 286-287 |
| 作者姓名： | 滕伟禹 邹仁林 曹云鹏 吴哲 汤浩 |
| 作者单位： | 1. 中国医科大学附属第一医院神经内科,辽宁,沈阳,110001 2. 瓦房店市第三医院神经内科,辽宁,瓦房店,116300 3. 中国医科大学基础医学院生理教研室,辽宁,沈阳,110001 |
| 摘 要： | 目的 探讨一氧化氮（ＮＯ）、超氧化物歧化酶（ＳＯＤ）分别及联合使用对大鼠实验性蛛网膜下腔出血（ＳＡＨ）后脑血管痉挛（ＣＶＳ）时脑血流（ＣＢＦ）的作用。方法 将３０只大鼠随机分成５组（每组６只）。Ａ组：假手术＋盐水，Ｂ组：ＳＡＨ＋盐水；Ｃ组：ＳＡＨ＋ＳＯＤ；Ｄ组：ＳＡＨ＋ＮＯＣ１２；Ｅ组：ＳＡＨ＋ＳＯＤ、ＮＯＣ１２。模拟制成４８ｈ后，通过Ｌａｓｅ－Ｄｏｐｐｌｅｒ血液仪观察各种药物持续静脉注射１ｈ内Ｃ |
| 关 键 词： | 蛛网膜下腔出血 脑血管痉挛 一氧化氮 SOD |
| 修稿时间： | 1999-11-01 |
Effects of nitric oxide and superoxide dismutase on cerebral blood flow in cerebral vasospasm after experimental subarachnoid hemorrhage in rats |
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| TENG Wei yu,ZOU Ren lin,CAO Yun peng,et al.. Effects of nitric oxide and superoxide dismutase on cerebral blood flow in cerebral vasospasm after experimental subarachnoid hemorrhage in rats[J]. Journal of Apoplexy and Nervous Diseases, 2000, 17(5): 286-287 | |
| Authors: | TENG Wei yu ZOU Ren lin CAO Yun peng et al. |
| Abstract: | Objectives To explore the effects of nitric o xide(NO) and superoxidedismutase（SOD） respectively and combinedly used on cer ebral blood flow（CBF） incerebral vasospasm of experimental subarachnoid hemor r hage（SAH） in rats. Methods 30rats were divided into fi ve groups（n=6）. Apsudosurgery＋Saline；BSAH＋Saline；Cpsudosurgery＋NOC12；DSAH＋NOC12；ESAH＋NOC12＋SOD. 48 hours after model was made， changes of CBFduring venous injection of various drugs were observed continuously with Laser－ Dopplerfor 1 hour. Results CBF showed no change in group A and B，but marked increase in groupC、D and E，but the increase in group E w ere more significant than that in group C andD. Conclusions Both NO and SOD increase CBF of CVS， and combined use of them showbetter effects than sing le. |
| Keywords: | Subarachnoid hemorrhage Cerebral vasospasm Nitric oxide Superoxide dismutase Cerebral blood flow |
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