69例少精、无精症患者血清性激素水平分析

目的探讨少精、无精症患者血清性激素检测的临床应用价值。方法采用化学发光免疫分析法(CLIA)测定21例无精症、48例少精症(其中13例为重度少精症)患者与25例精液正常健康体检男性的血清性激素水平。结果无精症组及重度少精症组卵泡刺激素(FSH)、黄体生成素(LH)均显著高于正常精液组(P<0.01),且FSH升高幅度均大于LH。少精症组FSH、LH虽较正常精液组高,但无显著性意义(P>0.05)。与正常精液组比较,无精症组、少精症组、重度少精症组垂体催乳素(PRL)均呈显著性升高(P<0.01),睾酮(T)均呈显著性降低(P<0.01),而雌二醇(E2)、孕酮(P)均无显著性变化(P>0.05)。无精症组FSH、LH、PRL升高者分别占66.7%、61.9%和28.6%,T降低者为42.9%;重度少精症组FSH、LH、PRL升高者分别为53.8%、38.5%和30.8%,T降低者为38.5%。FSH、LH、T均呈降低者,无精症组14.3%,重度少精症组7.7%;FSH、LH升高而T在正常参考范围者,无精症组38.1%,重度少精症组23.1%;FSH、LH升高而T降低者,无精症组23.8%,重度少精症组15.4%;FSH、LH、T均在正常参考范围者,无精症组19.0%,重度少精症组23.1%。结论血清性激素水平检测应用于少精症(特别是重度少精症)、无精症患者的病因分析、制定治疗措施和预后判断具有重要的临床意义。

Analysis of serum sex hormone in 69 patients with oligospermia and azoospermia

Objective To investigate the clinical value of the determinations of serum sex hormone in patients with oligospermia and azoospermia.Methods Serum sex hormone levels of 21 patients with azoospermia, 48 patients with oligospermia (there were 13 patients with severe oligospermia among them) and 25 healthy men with normal semen as normal control were determined by chemiluminescent immunoassay (CLIA).Results FSH and LH in azoospermia and severe oligospermia were all significantly higher than that in normal semen (P<0.01), and FSH was raised more highly than LH each other. FSH and LH in oligospermia were higher than that in normal semen, but the differences were not significant (P>0.05). Compared with that in normal semen, in azoospermia, oligospermia and severe oligospermia, PRL was significantly higher (P<0.01), T was significantly lower (P<0.01), but E2 and P did not alter significantly (P>0.05), respectively. The rates of which showed FSH increasing, LH increasing, PRL increasing, and T reducing respectively were 66.7%, 61.9%, 28.6% and 42.9 % in azoospermia, and 53.8%, 38.5%, 30.8% and 38.5% in severe oligospermia. The rates of which showed FSH, LH and T reducing together were 14.3% in azoospermia and 7.7% in severe oligospermia; the rates of which showed FSH, LH increasing but T in the normal reference range were 38.1% in azoospermia and 23.1% in severe oligospermia; the rates of which showed FSH, LH increasing but T reducing were 23.8% in azoospermia and 15.4% in severe oligospermia; the rates of which showed FSH, LH and T in the normal reference range together were 19.0 % in azoospermia and 23.1% in severe oligospermia.Conclusion The determination of serum sex hormone is of clinical importance for the etiological analysis, the treatment and the prognostic judgement of oligospermia (severe oligospermia especially) and azoospermia.