腹腔G^＋、G^-菌感染致MODS血清中炎性因子与预后的关系

目的：探讨腹腔G^＋、G^-菌感染致MODS患者血清中炎性因子与预后的关系。方法：将2009年4月～2010年3月在本院综合ICU救治的27例腹腔G^＋、G^-菌感染致MODS患者分为存活组和死亡组,采用酶联免疫吸附法（ELISA）分别检测两组第1、4、7天血清中IL-6、IL-8、IL-10、TNF-α浓度。结果：存活组血清中炎性因子IL-6、IL-10浓度水平呈持续下降趋势（P〈0.05）,而IL-8、TNF-α浓度变化不大（P〉0.05）;死亡组血清中炎性因子IL-6浓度水平呈持续上升趋势（P〈0.05）,而IL-8、IL-10、TNF-α浓度变化不大（P〉0.05）;死亡组IL-6、IL-10、TNF-α的浓度水平明显高于存活组（P〈0.05）。结论：连续监测血清中IL-6、IL-10、TNF-α的浓度,对于腹腔G^＋、G^-菌感染致MODS患者预后的判断有重要的参考价值。

Analysis of peritoneal G+, G- bacteria infection on serum inflammatory factors and MODS prognosis

Objective：To explore the abdominal cavity G^＋,G^-bacteria infection caused by MODS in patients with inflammatory factors and prognosis.Methods：From April 2009 to March 2010 comprehensive ICU treatment in our hospital,27 cases of abdominal G^＋,G^-bacteria infection on the survival of MODS patients were divided into groups and the death group,using enzyme-linked immunosorbent assay（ELISA）were used to detect the first two days 1,4,7 serum IL-6,IL-8,IL-10,TNF-α concentration.Results：Survival of serum inflammatory factor IL-6,IL-10 concentrations showed a decreasing trend（P〈0.05）,while IL-8,TNF-α concentration was not（P〉0.05）;death of serum inflammatory factor IL-6 concentrations tend to increase（P〈0.05）,while IL-8,IL-10,TNF-α concentration was not（P〉0.05）;death group IL-6,IL-10,TNF-α concen tration was significantly higher than the survival group（P〈0.05）.Conclusion：Continuous monitoring of serum IL-6,IL-10,TNF-α concentrations,for abdominal G^＋,G^-bacteria infection on the prognosis of MODS patients has important reference value.