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Association of Thrombin Generation Potential with Platelet PAR-1 Regulation and P-Selectin Expression in Patients on Dual Antiplatelet Therapy |
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| Authors: | Roza Badr Eslam Florian Posch Irene M. Lang Thomas Gremmel Beate Eichelberger Cihan Ay Simon Panzer |
| Affiliation: | 1. Department of Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria 2. Department of Medicine I, Clinical Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria 3. Department of Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria 4. Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria |
| Abstract: | We studied the association of thrombin generation potential with platelet protease activated receptor (PAR)-1 regulation and platelet activation in 52 stable coronary artery disease patients on continuous therapy with aspirin and clopidogrel (n?=?42) or prasugrel (n?=?10). Compared to controls, peak thrombin generation potential was elevated in only 11 patients (p?>?0.05), while F1.2 was elevated in 26 patients (p?p?p?=?0.002), suggesting in vivo depletion of platelet alpha granules due to ongoing platelet activation. |
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