胆红素水平与冠心病发病、血脂水平相关关系的研究

目的　就胆红素水平与冠心病 (CHD)发病及血脂水平是否相关进行对照研究。方法　设定CHD组(10 0例 )与对照组 (6 0例 ) ,测定血清总胆红素 (TBIL)、甘油三酯 (TG)、总胆固醇 (CHO)、高密度脂蛋白 (HDL)、低密度脂蛋白胆固醇 (LDL -C) ,采用FRIEDWALD公式计算 (组间比较采用 t检验 )。结果　CHD组TBIL浓度明显低于对照组 (P <0 .0 5 ) ,CHD组TBIL浓度与LDL -C、TG呈一定的负相关。结论　CHD的发生与TBIL的降低有一定的相关性。TBIL具有防止脂质氧化的作用 ,从而防止CHD的发生

Study on correlativity of coronary heart disease,lipidemia and serum bilirubin

Objective To study relations of serum bilirubin level, coronary heart disease(CHD) and lipid level.Methods Serum bilirubin(TBIL),triglycerides(TG),total cholesterol(CHO),high density lipoproteins cholesterol(HDL-C) and of CHD group(100 samples) and low density lipoproteins cholesterol(LDL-C) control group(60 samples) were mensurated.It used for FRIEDWALD formula (analysis with t method).Results The concentration of total bilirubin in CHD group was lower than that in the control group(P<0.05).The concentration of total bilirubin in CHD group shows negative correlativity with concentration of low density lipoproteins cholesterol(LDL-C) and triglycerides (TG).Conclusions Lower serum bilirubin is associated with increased risk for coronary heart disease. Serum bilirubin could prevent lipid from oxygenation, thus avoid the happening of CHD.