| 4-甲基-3-溴苯酚合成的改进 |
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| 引用本文： | 任志强,秦丙昌. 4-甲基-3-溴苯酚合成的改进[J]. 广东化工, 2014, 0(8): 33+36-33,36 |
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| 作者姓名： | 任志强 秦丙昌 |
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| 作者单位： | 安阳师范学院化学化工学院,河南安阳455000 |
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| 摘 要： | 对4-甲基-3-溴苯酚的合成进行了改进:简化了溴化反应的后处理步骤,解决了还原反应的后处理中Sn(OH)2胶体沉淀难以破坏的问题,改进了重氮盐水解反应的操作方法。按照改进的方法,以4-硝基甲苯为起始原料经4步反应合成目标化合物,总收率为53%。
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| 关 键 词： | -甲基--溴苯酚 -硝基甲苯 -硝基--溴甲苯 -甲基--溴苯胺 |
Improvements on Synthesis of 3-Bromo-4-methylphenol |
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| Ren Zhiqiang,Qin Bingchang. Improvements on Synthesis of 3-Bromo-4-methylphenol[J]. Guangdong Chemical Industry, 2014, 0(8): 33+36-33,36 |
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| Authors: | Ren Zhiqiang Qin Bingchang |
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| Affiliation: | (College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China) |
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| Abstract: | Synthesis of 3-bromo-4-methylphenol was improved： after treatment of the bromination was simplified; the problem that Sn（OH）2 colloidal sediment hard to destroy was solved in after treatment of the reduction; hydrolysis process of the diazonium salt was improved. On the basis of above improvement, the target compound was synthesis in 53% yield with p-nitrotoluene as raw materials by four steps. |
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| Keywords: | 3-bromo-4-methylphenol 4-nitrotoluene： 2-bromo4-nitrotoluene： 3-bromo-4-methylaniline |
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