| CX3CR1基因多态性与冠心病关联的荟萃分析 |
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| 引用本文： | 李文龙,王晓建,徐菁,陈敬洲,张禅那,孙凯,惠汝太. CX3CR1基因多态性与冠心病关联的荟萃分析[J]. 基础医学与临床, 2009, 29(11) |
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| 作者姓名： | 李文龙 王晓建 徐菁 陈敬洲 张禅那 孙凯 惠汝太 |
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| 作者单位： | 北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037;北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037;北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037;北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037;北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037;北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037;北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京,100037 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 目的 探讨CX3CR1-V249I、T280M与冠心病(CAD)的关联性.方法 检索中英文数据库,以得到CX3CR1-V249I、T280M与CAD易感性关系的病例对照研究,采用Meta分析方法 合并V249I、T280M与CAD关联的OR值,同时进行文献发表偏倚检验.结果 共纳入文献6篇.对于V249I,共纳入病例1 551人,对照1 804人,I型相对于V型合并OR=0.85(95%CI=0.67～1.08,P＞0.05);对于T280M,共纳入病例1 555人,对照1 801人,M型相对于T型合并OR=0.82(95%CI=0.70～0.96,P＜0.05).结论 T280M为CAD的保护性因素,V249I与CAD的发生无关联.Abstract：Objective To find whether CX3CR1 V249I and T280M are associated with CAD. Methods Database in English and Chinese, including PUBMED, EMbase, were searched to get the case-control studies on the associa-tion between V249I, T280M and CAD. Results Six studies were reviewed. The pooled OR of V249I compared to wild type allele was OR =0. 85(95% CI =0. 67 ～ 1. 08,P >0. 05). The pooled OR of T280M compared to wild type allele was OR =0. 82(95% CI =0. 70 ～ 0. 96, P < 0. 05). Conclusion The T280M is a protective factor of CAD, while the V249I is not associated with CAD.
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| 关 键 词： | 冠心病 CX3CR1 基因多态性 |
Relationship between polymorphisms of CX3CR1 gene and coronary artery disease: a Meta-analysis |
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| LI Wen-long,WANG Xiao-jian,XU Jing,CHEN Jing-zhou,ZHANG Chan-na,SUN Kai,HUI Ru-tai. Relationship between polymorphisms of CX3CR1 gene and coronary artery disease: a Meta-analysis[J]. Basic Medical Sciences and Clinics, 2009, 29(11) |
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| Authors: | LI Wen-long WANG Xiao-jian XU Jing CHEN Jing-zhou ZHANG Chan-na SUN Kai HUI Ru-tai |
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| Abstract: | Objective To find whether CX3CR1 V249I and T280M are associated with CAD. Methods Database in English and Chinese, including PUBMED, EMbase, were searched to get the case-control studies on the associa-tion between V249I, T280M and CAD. Results Six studies were reviewed. The pooled OR of V249I compared to wild type allele was OR =0. 85(95% CI =0. 67 ～ 1. 08,P >0. 05). The pooled OR of T280M compared to wild type allele was OR =0. 82(95% CI =0. 70 ～ 0. 96, P < 0. 05). Conclusion The T280M is a protective factor of CAD, while the V249I is not associated with CAD. |
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| Keywords: | CX3CR1 |
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