急性加重期慢性阻塞性肺疾病血清可溶性髓系细胞触发受体一1水平的变化及其临床意义

目的探讨早期测定血清可溶性髓系细胞触发受体．1（sTREM．1歹在诊断急性加重期慢性阻塞性肺疾病（AECOPD）患者合并肺部细菌感染中的价值。方法应用定量酶联免疫吸附法（ELISA）检测60例AECOPD患者的血清sTREM-1水平，并将sTREM．1水平与临床肺部感染评分（CPIS）进行相关性分析。结果AECOPD在细菌感染组血清sTREM-1水平明显高于无细菌感染组（P均〈0．05）。根据ROC曲线，sTREM．1曲线下面积为0．930，95％可信区间为0．840—1．020，诊断效能好。且与CPIS评分呈正相关（r=0．246，P〈0．05）。结论早期测定血清sTREM-1水平对AECOPD患者合并肺部细菌感染的诊断有一定价值，可以为病情或感染严重程度的评估提供有意义的参考指标。

The changes of serum soluble triggering receptor expressed on myeloid cell-1 level in AECOPD patients andits clinical significance

Objective To explore the value of serum soluble triggering receptor expressed on myeloid cell-1 （sTREM-1） in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease（AECOPD） patients with lung bacterial infection. Methods The sTREM-1 level was detected by ELISA method and the further relevant analysis between sTREM-1 level and clinical lung infection score （CPIS） was performed. Results The level of sTREM-1 in bacterial infection group was significantly higher than that in no bacterial infections group （ P 〈 0. 05 ）. According to the ROC curves of sTREM-1, AUC was 0. 930, 95% CI ranged from 0. 840 to 1. 020, the efficiency of diagnosis was prominent. And level of sTREM-1 had of the positive correlation with CPIS score （r = 0. 246, P 〈 0. 05 ）. Conclusion The early determination of the level of sTREM-I has certain value in diagnose of AECOPD patients with pulmonary bacteria infection, and provide positive reference for evaluating severity of illness or infection.