| An Improved Synthesis of Retinoic Acid from β-Ionone |
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| 引用本文： | Yao Dong HUANG Xiao Jie ZHANG 等.An Improved Synthesis of Retinoic Acid from β-Ionone[J].中国化学快报,2003,14(1):29-31. |
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| 作者姓名： | Yao Dong HUANG Xiao Jie ZHANG |
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| 作者单位： | DepartmentofChemistry,FudanUniversity,Shanghai200433 |
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| 摘 要： | A convenient and large-scale preparation of retinoic acid 1 from β-ionone in five steps with 38% overall yield is described.The key steps are the epoxidization of 2 with a new methylated agent and the condensation 4 with tetraethyl methylenediphophonate in one-pot procedure to prepare 6.
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| 关 键 词： | 视黄酸 合成 β-芷香酮 痤疮 皮肤病治疗药物 WHE反应 |
An Improved Synthesis of Retinoic Acid from β-Ionone |
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| Yao Dong HUANG,Xiao Jie ZHANG,Ze Xu WANG,Fen Er CHEN.An Improved Synthesis of Retinoic Acid from β-Ionone[J].Chinese Chemical Letters,2003,14(1):29-31. |
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| Authors: | Yao Dong HUANG Xiao Jie ZHANG Ze Xu WANG Fen Er CHEN |
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| Abstract: | A convenient and large-scale preparation of rctinoic acid 1 from β-ionone in five steps with 38% overall yield is described. The key steps are the epoxidization of 2 with a new methylated agent and the condensation 4 with tetraethyl methylenediphophonate in one-pot procedure to prepare 6. |
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| Keywords: | Retinoic acid trimethylsulfonium p-tolenesulfonate allylic phosphonate Wittig- Horner-Emmons (WHE) reaction synthesis |
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