| 肝纤维化中上皮间质转化的调控及靶向治疗的研究进展 |
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| 引用本文： | 王永娟,谢肖立,姜慧卿.肝纤维化中上皮间质转化的调控及靶向治疗的研究进展[J].临床肝胆病杂志,2021,37(1):165-168. |
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| 作者姓名： | 王永娟 谢肖立 姜慧卿 |
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| 作者单位： | 河北医科大学第二医院消化内科,河北省消化病重点实验室,河北省消化病研究所,石家庄050000;河北医科大学第二医院消化内科,河北省消化病重点实验室,河北省消化病研究所,石家庄050000;河北医科大学第二医院消化内科,河北省消化病重点实验室,河北省消化病研究所,石家庄050000 |
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| 基金项目： | 国家自然科学基金资助项目(81770601);河北省研究生创新资助项目(CXZZBS2018076);河北省重点研发计划项目(182777117D)。 |
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| 摘 要： | 肝纤维化的病理基础是细胞外基质沉积,肌成纤维细胞是细胞外基质的主要来源。上皮间质转化(EMT)是肌成纤维细胞的产生机制之一。目前大量研究表明,以EMT关键分子及信号通路为靶点进行干预,可减轻肝纤维化。回顾了相关文献,对EMT相关的信号通路、重要调控分子和以EMT为靶点治疗肝纤维化的药物进行综述,以期为治疗肝纤维化提供新思路。
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| 关 键 词： | 肝硬化 上皮-间质转化 治疗学 |
Research advances in the regulation of epithelial-mesenchymal transition and targeted therapy for liver fibrosis |
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| WANG Yongjuan,XIE Xiaoli,JIANG Huiqing.Research advances in the regulation of epithelial-mesenchymal transition and targeted therapy for liver fibrosis[J].Chinese Journal of Clinical Hepatology,2021,37(1):165-168. |
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| Authors: | WANG Yongjuan XIE Xiaoli JIANG Huiqing |
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| Affiliation: | (Department of Gastroenterology,The Second Hospital of Hebei Medical University,Hebei Key Laboratory of Gastroenterology,Hebei Institute of Gastroenterology,Shijiazhuang 050000,China) |
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| Abstract: | The pathological basis of liver fibrosis is the deposition of extracellular matrix(ECM),and myofibroblasts are the main source of ECM.Epithelial-mesenchymal transition(EMT)is one of production mechanisms of myofibroblasts.At present,a large number of studies have shown that intervention of key EMT molecules and signaling pathways as targets can reduce liver fibrosis.Based on literature review,this article summarizes the signaling pathways associated with EMT,important regulatory molecules,and drugs targeting EMT in the treatment of liver fibrosis,so as to provide new ideas for the treatment of liver fibrosis. |
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| Keywords: | Liver Cirrhosis Epithelial-Mesenchymal Transition Therapeutics |
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