血清白介素-10水平与2型糖尿病大血管并发症关系的研究

目的探讨血清白介素-10（IL-10）水平与2型糖尿病（T2DM）大血管并发症的关系。方法选择84例T2DM患者，其中T2DM伴大血管病变者50例（大血管病变组）、T2DM无大血管病变者34例（单纯糖尿病组）。另选择50例健康体检者为正常对照组。采用ELISA试剂盒检测3组受检者血清IL-10水平。结果糖尿病大血管病变组患者血清IL-10水平显著低于正常对照组[（2．7±0．9）ng／L与（4．5±1．6）ng／L]，差异有统计学意义（P〈0．05）；单纯糖尿病组血清IL-10水平与正常对照组比较[（4．0±1．4）ng／L与（4．5±1．6）ng／L]，差异无统计学意义（P〉0．05）。结论T2DM伴大血管病变患者血清IL-10明显降低；提示炎症参与了T2DM大血管并发症的发生、发展；IL-10可能是T2DM大血管病变的危险因素和预测因子之一。

Relationship between Plasma IL-10 Level and T2DM Macrovascular Complications

Objective To investigate the relationship between plasma IL-10 levels and T2DM macrovascular complications.Methods A total of 84 T2DM patients were enrolled,including 50 with macrovascular lesions (group A) and 34 without (group B).Anther 50 healthy subjects were chosen as control group.Serum IL-10 levels were detected by ELISA kits in 3 groups.Results The levels of serum IL-10 were lower in group A than in control (2.7±0.9 ng/L,4.5±1.6 ng/L,respectively),the difference was significant (P＜0.05).There was not significant difference in IL-10 levels between groups B and control(P＞0.05).Conclusion Low-IL-10 hyperlipidemia exists in T2DM patients with macrovascular lesions,suggesting that inflammation is involved in the occurrence and development of T2DM macrovascular complications.IL-10 may be one of the risk factors and predictors of T2DM macrovascular lesions.