视神经炎发展为多发性硬化的危险因素分析

目的:分析视神经炎发展为多发性硬化(multiple sclerosis,MS)的危险因素。方法:对比分析6例发展为MS的视神经炎患者和其余45例视神经炎患者的临床资料,寻找视神经炎发展为多发硬化的危险因素。结果:发展为MS的视神经炎复发率比其他视神经炎高(P<0.01),眼球周围疼痛较其他视神经炎多见,但无统计学意义(P=0.18)。性别、年龄、单侧或双侧发病、视力下降程度、视盘水肿等方面均未见明显差异。血沉高于正常的视神经炎患者较血沉正常的患者更不易发展为MS(P<0.05)。结论:对于复发的、存在眼球周围疼痛的视神经炎患者要重点关注其发展为MS的可能。视神经炎患者应常规行血沉检查。最好以头颅MRI检查替代头颅CT检查,条件允许时检查脊髓MRI。

Prognostic factors of MS after optic neuritis

AIM:To explore the prognostic factors for the develop-ment of multiple sclerosis (MS) following optic neuritis.·METHODS:We followed in a retrospective study (2003-2006) of 51 patients with optic neuritis.Six of them were verified MS at last.·RESULTS:Recurrence of MS optic neuritis elevated the risk significantly (P<0.01).The pain around eyes was more common than other optic neuritis,but it had no statistical significance (P=0.18).There were no signifi-cant differences on sex,age,one/double side occurren-ce,decrease degree of visual acuity,and papilloedema etc.Erythrocyte sedimentation rate (ESR) was associated with a lower risk of multiple sclerosis.·CONCLUSION:The risk of MS in this large population-based prospective ON patient series is 12% and signi-ficantly higher in those which recurrence.ESR is recom-mended to be examined at onset.·