达英-35治疗多囊卵巢综合征的短期疗效观察

目的:探讨达英-35(diane-35,每片含醋酸环丙孕酮CAP2mg和乙炔雌二醇EE35mg)对多囊卵巢综合征(PCOS)患者短期治疗效果。方法:选择40例1年内暂无生育要求的多囊卵巢综合征患者,随机分为两组,即A组:达英-35治疗3个周期,B组:达英-35治疗6个周期,每组各20例,治疗前、治疗结束时及停药后3个月分别测定性激素6项,观察月经恢复情况及用药期间的副反应。结果:治疗3个周期后所有患者月经周期规律,停药后多可维持1个月,黄体生成素及睾酮下降明显,差异有显著性,P<0.05;治疗6个周期后,黄体生成素及睾酮下降更明显,P<0.01,其临床典型的内分泌症状明显改善,规律月经周期可维持2～3个月。结论:达英-35短期内治疗多囊卵巢综合征有良好的疗效,对于1年内暂无生育要求的患者,6个周期疗效优于3个周期。

Short- term effects of Diane- 35 on polycystic ovary syndrome

Objective:To investigate the short-term effects of Diane-35 on polycystic ovary syndrome(PCOS).Methods:40 non-bear within one year PCOS women were enrolled into study.They were divided into two groups randomly:group A was given Diane-35 for 3 cycles:group B was given Diane-35 for 6 cycles,their sex hormones in pretreatment,at the end of treatment and drug withdrawal 3 month were detected,at same time,their menstruation and adverse reaction were observed.Results:All women had menstrual cycle after 3 treatment cycles with Diane-35,and can kept one cycle after withdrawal.The levels of LH and T after withdrawal were lower than those in pretreatment(P<0.05),after 6 treatment cycles,the levels of LH and T were significantly lower than those in pretreatment(P<0.01).The endocrine symptoms improved obviously,and menstrual cycle could keep 2～3 months.Conclusion:The short-term effect for women with polycystic ovary syndrome by Diane-35 is good.Six cycles is better than three cycles in Diane-35 treatment for PCOS non-bear within one year.