放射性核素骨显像骨代谢与骨密度的相关性分析

目的：探讨放射性核素骨显像骨代谢与骨密度的相关性,通过骨显像了解骨质疏松状况.方法：18例患者,男5例,女13例,年龄50～88岁,平均65岁.所有患者均通过骨密度扫描仪进行骨密度检查后,进行全身骨显像.骨显像与骨密度检查均取第L1～L4和股骨颈,并勾画感兴趣区（ROI）,然后分别测定各部位ROI放射性计数和骨密度值,计算骨显像各部位ROI值与同侧股骨中段ROI值的比值,观察各部位ROI比值与其骨密度值之间的相关性.结果：骨显像L1～L4各部位ROI比值与其骨密度值呈显著相关,而且,正常组与骨质疏松组的ROI比值与骨密度的相关性存在显著性差异.股骨颈的ROI比值与其骨密度无显著相关.骨显像L1～L4的ROI比值与其相应部位骨密度测定值之间变化趋势基本一致.结论：放射性核素SPECT骨显像腰椎ROI比值与其对应部位的骨密度值之间均呈显著相关,可通过其反映腰椎骨密度的变化.

Correlation between bone metabolism by radionuclide bone imaging and bone mineral density

Objective： To study the correlation between bone metabolism through radionuclide bone imaging and bone mineral density （BMD） by bone density scanning to provide valuable information about the status of osteoporosis. Methods： Eighteen patients, 5 male and 13 female, age ranged from 50 to 88 years old with an average of 65 years old were included in this study. All of the patients underwent a bone density scanning （GE Lunar DXA） for bone density estimation, SPECT whole-body bone scan（GE Infinia Hawkeye, 4） were performed. The region of interest（ROI） was separately put at tst-4th lum- bar vertebrae and femoral neck for radioactivity absorption examination and also BMD measurement. The ROI ratio was the detected part ROI value divided by the respective ipsilateral middle femur shaft ROI value. Correlation analysis between bone metabolism and bone density were carried out. Results： The ROI ratio of L1-L4 bone radionuclide scintigraphy and BMD had significant correlation. The ROI ratio of the normal group and osteoporotic group also had significant correlation with that of the BMD. The ROI ratio of the femoral neck had no significant correlation with that of the BMD. The changes of ROI ratio of L1-L4, had the same trend as that of the BMD of the respective region. Conclusion： The ROI ratio of the lumbar vertebrae through radionuclide bone sctintigraphy has significant correlation with that of BMD, therefore can be used as estimation of BMD.