| 脂质体的电性对水杨酸铜SOD样活性的影响(英文) |
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| 引用本文： | 刘艳,贾彩,侯新朴. 脂质体的电性对水杨酸铜SOD样活性的影响(英文)[J]. 中国药学, 2001, 0(2) |
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| 作者姓名： | 刘艳 贾彩 侯新朴 |
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| 作者单位： | 北京大学药学院!北京100083 |
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| 摘 要： | 采用细胞色素c法研究了水杨酸铜分别在中性、正负电性脂质体中SOD样活性的变化情况。证明中性脂质体包裹的水杨酸铜的SOD样活性比水杨酸铜在水溶液中提高了3倍多。但正负电性脂质体包裹的水杨酸铜的SOD样活性降低。并发现在实验浓度范围内，负电性脂质体包裹的水杨酸铜，活性变化无规则，且荷负电量多的脂质体包裹的水杨酸铜促进超氧自由基的歧化，而荷负电量少的脂质体仅在低浓度区对超氧的歧化表现为促进作用。
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| 关 键 词： | 超氧自由基 SOD样活性 脂质体 铜络合物 |
The Effect of Electric Properties of Liposomes on SOD-like Activity of Copper Salicylate |
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| Liu Yan,Jia Cai and Hou Xinpu School of Pharmaceutical Sciences,Peking University,Beijing. The Effect of Electric Properties of Liposomes on SOD-like Activity of Copper Salicylate[J]. Journal of Chinese Pharmaceutical Sciences, 2001, 0(2) |
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| Authors: | Liu Yan Jia Cai Hou Xinpu School of Pharmaceutical Sciences Peking University Beijing |
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| Affiliation: | Liu Yan,Jia Cai and Hou Xinpu School of Pharmaceutical Sciences,Peking University,Beijing 100083 |
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| Abstract: | The SOD-like activities of copper salicylate encapsulated in neutral, positively and negatively charged liposomes were studied with cytochrome c method. The results showed that the SOD-like activity of copper salicylate encapsulated in neutral liposomes was enhanced over 3 times more than that of copper salicylate in aqueous solution. However, the activity decreased for copper salicylate encapsulated in positively and negatively charged liposomes. It was also found that at experimental concentrations there was no regularity for the change of activity of copper salicylate encapsulated in negatively charged liposomes, and copper salicylate encapsulated in liposomes with more negative charges could promote the dismutation of superoxide anion free radicals, however, so could copper salicylate encapsulated in liposomes with fewer negative charges only in lower concentrations. |
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| Keywords: | Superoxide radical SOD-like activity Liposome Copper complex |
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