红芪活性成分免疫调节作用及机制研究进展

免疫功能受损或免疫系统紊乱会导致机体疾病发生,影响人身体健康,基于调节机体免疫治疗疾病已成为临床应用热点。红芪作为甘肃大宗药材,临床应用广泛,具有抗肿瘤、抗炎、免疫调节等多种药理作用。红芪活性成分主要有红芪多糖、黄酮类、萜类、皂苷类等,其中红芪多糖为红芪发挥免疫调节作用主要的物质基础。红芪增强机体免疫力主要体现在增强免疫器官功能,诱导免疫细胞分化、促进免疫因子分泌,提高单核巨噬细胞吞噬功能、调节炎性因子水平以及激活相关通路等方面来达到其抗肿瘤、抗炎作用。本文主要对红芪活性物质免疫调节作用进行阐述,为红芪的进一步临床开发应用提供思路。

Research progress on immunoregulatory effect and mechanism of active components of radix astragali

Impaired immune function or immune system disorder will lead to the occurrence of body diseases and affect people"s health. The method of regulating body immunity to treat diseases has become a hot spot in clinical application. Hedysari Radix is a bulk medicinal material in Gansu, widely used in clinical, with anti-tumor, anti-inflammatory, immune regulation and other pharmacological effects. The active components mainly include polysaccharides, flavonoids, terpenoids, saponins, etc. among them, polysaccharides of Hedysari Radix are the main material basis for Hedysari Radix to play an immunomodulatory role. The enhancement of immunity by Hedysari Radix also depends on its anti-tumor and anti-inflammatory effects, which are mainly reflected in enhancing the function of immune organs, inducing the differentiation of immune cells, promoting the secretion of immune factors, improving the phagocytosis of mononuclear macrophages, regulating the level of inflammatory factors and activating related pathways. This article mainly expounds the active substances of Hedysari Radix, which provides a theoretical basis for the study of clinical immunity of Hedysari Radix.