橙皮苷药理作用及机制的研究进展

橙皮苷广泛存在于柑橘属、芸香科、茜草科、唇形科、十字花科植物果实或根茎中，是一种二氢黄酮类化合物，也是中药陈皮、枳实、枳壳、款冬花等的主要药效成分，属于维生素P类药，可增强毛细血管的韧性、缩短出血时间，临床多用于心血管系统疾病的辅助治疗，在食品工业中可用作天然抗氧化剂，也可用于化妆品行业。现代药理研究表明橙皮苷具有抗炎、抗氧化、保护心血管系统、抗糖尿病并发症、抗菌、抗肿瘤、提升免疫力、保护神经系统等多种生物学活性，因此，通过对橙皮苷的药理作用及机制进行归纳总结，以期为其临床应用及药物开发提供依据。

Research progress on pharmacological action and mechanism of hesperidin

Hesperidin is widely found in the fruits or roots of Citrus, Rutaceae, Rubiaceae, Labiaceae and Cruciferae plants. It is a dihydroflavonoid compound, and it is also the main pharmacodynamic component of Chenpi (Citri Reticulatae Pericarpium), Zhishi (Aurantii Fructus Immaturus), Zhiqiao (Aurantii Fructus) and Kuandonghua (Farfarae Flos). It belongs to the class of vitamin P drugs, which can enhance the toughness of capillaries and shorten the bleeding time. It is often used in the auxiliary treatment of cardiovascular system diseases. It can be used as a natural antioxidant in the food industry and also in the cosmetics industry. Modern pharmacological studies have shown that hesperidin has many biological activities such as anti-inflammatory, antioxidant, protection of cardiovascular system, anti-diabetic complications, antibacterial, antitumor, enhancement of immunity, protection of nervous system, etc. Therefore, the summarization of the pharmacological effects and mechanisms of hesperidin provide a basis for its clinical application and drug development.