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Male-pattern baldness susceptibility locus at 20p11 |
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| Authors: | Richards J Brent Yuan Xin Geller Frank Waterworth Dawn Bataille Veronique Glass Daniel Song Kijoung Waeber Gerard Vollenweider Peter Aben Katja K H Kiemeney Lambertus A Walters Bragi Soranzo Nicole Thorsteinsdottir Unnur Kong Augustine Rafnar Thorunn Deloukas Panos Sulem Patrick Stefansson Hreinn Stefansson Kari Spector Tim D Mooser Vincent |
| Affiliation: | Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK. |
| Abstract: | We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)). |
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