| 青霉素发酵过程菌丝成球的工程特性研究 |
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| 引用本文： | 张嗣良,叶勤,王永红,陆仕灿. 青霉素发酵过程菌丝成球的工程特性研究[J]. 医学教育探索, 1993, 0(5) |
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| 作者姓名： | 张嗣良 叶勤 王永红 陆仕灿 |
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| 作者单位： | 华东化工学院生化工程研究所(张嗣良，叶勤，王永红)，华东化工学院生化工程研究所(陆仕灿) |
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| 摘 要： | 研究了产黄青霉菌(P.chrysogenum)876菌株发酵过程中菌丝成球现象。菌丝成球后,由于在菌球内外形成一个氧浓度分布梯度,菌丝临界氧由25%提高至40%,从而对反应器供氧提出了更高的要求。一旦反应器供氧不足,菌体碳、氮源代谢能力减弱,不利于青霉素合成。这种代谢与工程因素的交互影响,为发酵过程优化控制提出了一个值得探讨的,既有理论学术价值又有实际意义的研究课题。
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| 关 键 词： | 青霉素 发酵 代谢 菌丝球 临界氧 |
Study on the Engineering Characteristic of the Mycelium Pellet in the Penicillin Fermentation |
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| Zhang Siliang,Ye Qin,Wang Yonghong and Lu Shican. Study on the Engineering Characteristic of the Mycelium Pellet in the Penicillin Fermentation[J]. Researches in Medical Education, 1993, 0(5) |
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| Authors: | Zhang Siliang Ye Qin Wang Yonghong Lu Shican |
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| Affiliation: | Research Institute of Biochemical Engineering |
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| Abstract: | The experimental results showed that the critical dissolve oxygen of the my celium rises from 25% to 40% because of the existence of oxygen concentration gradient in the pellet, and the mycelium needs more oxygen supplied by the bioreactor. Oxygen in short supply makes metabolism of carbon and nitrogen weak, which is unfavourable to synthesis of penicillin. The interaction of metabolism and engineering factors puts a valuable question for study. |
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| Keywords: | penicillin fermentation metabolism mycelium pellet critical oxygen |
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