Obesity Affects Short-Term Renal Function After Renal Transplantation |
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| Affiliation: | 1. Department of Urology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan;2. School of Medicine, Chang Gung University, Taoyuan, Taiwan;3. Chang Gung Transplant Institute, Taoyuan, Taiwan;4. Department of Urology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan;5. Department of Urology, New Taipei Municipal Tuchen Hospital, New Taipei City, Taiwan;1. Paulista School of Nursing, Federal University of São Paulo, São Paulo, Brazil;2. Nursing Department, Federal University of Santa Catarina, Florianópolis, Brazil;3. Nursing School, Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil;4. State Transplant Center, Secretary of Health of the State of São Paulo, São Paulo, Brazil;5. Health Department, Vale dos Sinos University, Porto Alegre, Brazil;1. Division of Transplantation Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;2. Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan;3. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;4. Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;1. Department of Medical Nutrition Therapy, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan;2. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan;3. Department of Urology, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan;4. Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei, Taiwan;5. Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan;6. Department of Nutrition and Health Sciences, Chinese Culture University, Taipei, Taiwan |
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| Abstract: | BackgroundThe literature has shown a significant association between body mass index (BMI) and patient and graft outcomes after renal transplantation. The purpose of this study was to reveal the effect of obesity on graft function in a Taiwanese kidney transplant cohort.MethodsTwo hundred consecutive patients who received kidney transplantation were enrolled in our study. Eight pediatric cases were excluded due to differing definitions of BMI among children. According to the national obesity criteria, these patients were divided into underweight, normal, overweight, and obese groups. Their estimated glomerular filtration rate (eGFR) was compared accordingly using t tests. Cumulative graft and patient survivals were calculated using Kaplan-Meier analysis. A P value of ≤ .05 was considered significant.ResultsThe mean age of our cohort (105 men and 87 women) was 45.3 years. There was no significant difference comparing biopsy-proven acute rejection, acute tubular necrosis, and delayed graft function between the obese and nonobese groups (P values: .293, .787, and .304, respectively). Short-term eGFR was inferior in the overweight group, but this effect was insignificant beyond 1 month. The 1-month and 3-month eGFR were found to be correlated with BMI groups (P = .012 and P = .008, respectively) but not significant after 6 months post–kidney transplantation.ConclusionsOur study found that short-term renal function was affected by obesity and being overweight, possibly due to the higher prevalence of diabetes and dyslipidemia in obese patients and the increased surgical difficulty. |
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