阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病的相关性分析

目的探讨阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病两者之间的相关性。方法研究对象为2010年5月~2013年3月来我院进行治疗的阻塞性睡眠呼吸暂停低通气综合征患者120例,将其以是否合并胃食管反流病分为两组,其中合并胃食管反流病为63例,未合并胃食管反流病者57例。OSAHS合并胃食管反流的患者采用莫沙必利、洛赛克及nCPAP治疗,采用统计学方法对结果进行分析。结果与轻度AHI、中度AHI患者比较,重度AHI患者所占的比例明显较高,三种程度患者的症状积分均具有显著性差异(P<0.05)。有GERD症状组患者的AHI及症状积分与无GERD症状组比较均明显较高,两组间具有显著性差异(P<0.05)。治疗后OSAHS合并GERD患者的AHI、DeMeester评分、立位及卧位pH<4时间百分比、卧位的最长酸反流时间均出现明显的降低,治疗前后具有显著性差异(P<0.05)。结论 OSAHS、GERD两种疾病之间具有密切的关系,可以互相影响。

Correlation analysis of obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease

Objective To investigate the effect of obstructive sleep apnea hypopnea syndrome is associated with gas troesophageal reflux disease. Methods The research object were selected from May 2010 to March 2013 in our hospi tal for treatment of 120 Obstructive sleep apnea hypopnea syndrome patients, There were divided into two groups ac cording to whether complicated with gastroesophageal reflux disease,one with gastroesophageal reflux disease were 63 cases, 57 cases without gastroesophageal reflux disease. OSAHS complicated with gastroesophageal reflux were treated with Mosapride,omeprazole and nCPAP,we used statistical analysis to analyze the results. Results Compared with mild AHI,moderate AHI patients,there were significantly higher in patients with severe AHI proportion, there were significant differences in symptom score among three degree （P〈0.05）. AHI and GERD symptoms in patients with symptoms of the integral group were significantly higher compared with no symptoms of GERD group, there was sig nificant difference between two groups （P〈0.05）. After treatment in patients with OSAHS GERD AHI, DeMeester score, standing and lying to pH〈4 time percentage, position the longest acid reflux time were obviously decreased, there were significant difference between after and before treatment（P〈0.05）. Conclusion There is a close relationship between the conclusion of OSAHS, GERD two kind of disease,can influence each other.