培美曲塞对化疗及靶向治疗失败的晚期肺腺癌的疗效观察 |
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引用本文: | 钟成,刘希光. 培美曲塞对化疗及靶向治疗失败的晚期肺腺癌的疗效观察[J]. 实用癌症杂志, 2016, 0(4): 569-571. DOI: 10.3969/j.issn.1001-5930.2016.04.015 |
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作者姓名: | 钟成 刘希光 |
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作者单位: | 266021,青岛大学医学院附属医院 |
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摘 要: | 目的 探讨培美曲塞对化疗及靶向治疗失败的晚期肺腺癌的治疗价值.方法 随机抽取2012年8月至2014年8月54例晚期肺腺癌患者的临床资料.按照临床治疗方法将患者分为实验组(28例)和对照组(26例).实验组采用培美曲塞单药化疗,对照组患者经常规治疗无效后采取其他化疗方案、支持治疗等措施.观察患者临床疗效、不良反应发生情况、生活质量变化情况.结果 实验组近期疗效优于对照组,差异有统计学意义(P<0.05).实验组不良反应发生率低于对照组,差异有统计学意义(P<0.05).实验组患者QOL总评分高于对照组,差异具有统计学意义(P<0.05).结论 培美曲塞治疗化疗及靶向治疗失败的晚期肺腺癌,可有效提高临床疗效,降低不良反应发生情况,改善患者生活质量.
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关 键 词: | 培美曲塞 化疗 靶向治疗 晚期肺腺癌 |
Clinical Efficacy of Pemetrexed for Advanced Lung Adenocarcinoma Failed Chemotherapy and Targeted Therapy |
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Abstract: | Objective To explore the clinical efficacy of pemetrexed for advanced lung adenocarcinoma failed chemo -therapy and targeted therapy .Methods 54 cases of advanced lung adenocarcinoma were divided into the experiment group ( 28 cases) and the control group(26 cases).The experiment group were treated by pemetrexed ,the control group were treated by oth-er methods.The clinical effects,side effects,QOL of the 2 groups were compared.Results The clinical effects of the experiment group was higher than that of the control group (P<0.05);The side effects of the experiment group were lower than that of the control group(P<0.05);The scores of QOL of the experiment group were higher than that of the control group (P<0.05).Con-clusion Pemetrexed for advanced lung adenocarcinoma failed chemotherapy and targeted therapy can improve clinical efficacy , reduce side effect ,and improve quality of life . |
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Keywords: | Pemetrexed Chemotherapy Targeted therapy Lung adenocarcinoma |
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