| 血清ConA非结合型GPDA检测及其临床应用 |
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| 引用本文： | 魏群,黄介飞,张弘,倪润洲,江枫,肖明兵,李峰,茅美云.血清ConA非结合型GPDA检测及其临床应用[J].中国交通医学杂志,2006,20(4):392-393. |
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| 作者姓名： | 魏群 黄介飞 张弘 倪润洲 江枫 肖明兵 李峰 茅美云 |
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| 作者单位： | 南通大学附属医院消化内科,江苏226001 |
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| 摘 要： | 目的:建立血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)糖链异质性的检测法。方法:利用伴刀豆素A(ConA)与等量血清孵育法测定血清中ConA非结合型GPDA。结果:正常人血清中ConA非结合型GPDA为12.1￣42.1U/L,原发性肝癌时明显升高。结论:本法简便,灵敏度高,有助于肝癌的早期诊断。
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| 关 键 词： | 原发性肝癌 甘氨酰脯氨酸二肽氨基肽酶 伴刀豆素A非结合型GPDA |
Detection of Serum ConA-non-reactive-glycoforms of glycylproline depeptidyl aminopeptidase and its clinical application |
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| Wei Qun,Huang Jiefei,Zhang Hong,et al.Detection of Serum ConA-non-reactive-glycoforms of glycylproline depeptidyl aminopeptidase and its clinical application[J].Chinese Medical JOurnal of Communications,2006,20(4):392-393. |
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| Authors: | Wei Qun Huang Jiefei Zhang Hong |
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| Affiliation: | Department of Gastroenterology ,the Affiliated Hospital of Nantong University,Jiangsu 226001 |
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| Abstract: | Objective:To establish the detection of serum glycoforms of glycylproline depeptidyl aminopeptidase(GPDA) sugar-chain heterogeneities.Methods:To utilize ConA and equivalence serum incubation to detect serum ConA-non-reactive-GPDA(GPDA-N-C).Results:The serum GPDA-N-C level is 12.1-42.1U/L in normal subjects,and is significantly higher in patients with primary hepatic carcinoma.Conclusion: This method is both simple and sensitive.GPDA-N-C is useful to the earlier period diagnosis of PHC. |
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| Keywords: | primary hepatic carcinoma(PHC) glycoforms of glycylproline depeptidyl aminopeptidase(GPDA) ConA-non-reactive-GPDA(GPDA-N-C) |
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