足月儿超声脑水肿相关因素多元Logistic回归分析

目的 通过对高危足月儿超声脑水肿相关因素的多元Logistic回归分析,探讨超声诊断脑水肿的临床价值.方法 经颅脑超声诊断为脑水肿患儿140例,选择同时间段,颅脑超声检查正常的足月儿152例作为对照组,对腩水肿的可能高危因素分别进行了单因素和多因素Logistic回归分析.结果 (1)在母亲是否有不良病史,是否发生官内窘迫、是否存在低蛋白血症的足月儿之间,脑水肿的发生率差异均无统计学意义,P>0.05.(2)单因素回归分析显示:出生窒息、缺血缺氧性脑病(HIE)、机械通气治疗、代谢性酸中毒是足月儿脑水肿的高风险因素.将上述因素收集起来,进行逐步Logistic回归分析,结果 HIE对高危足月儿超声脑水肿的发生有重要的作用,机械通气治疗在某种程度上可能与超声脑水肿的发生有关.结论 高危足月儿颅脑超声检查提示脑水肿与患儿HIE密切相关,提示超卢诊断脑水肿与临床实际相符,对指导临床诊断以及用药有辅助作用.

Multiple Logistic Regression Analysis of Risk Factors for Brain Edema Detected by Ultrasound Examination in Term Infants

Objective To study the clinic value of brain edema detected by ultrasound examination in high risk term infants. Meth-ods The study group included 140 term infants who were found having brain edema in cranial ultrasound examinations. 152 term infants with normal ultrasound scan were selected as a control group. The risk factors of brain edema were collected, and univariate analysis and multivariate logistic regression analysis were performed. Results (1) There was no difference of incidence of brain edema between the infants with or without maternal ill historys, fetal distress or hypoalbuminemia, with P > 0.05. (2) In the univariate regression model, as-phyxia,hypoxic -ischemic encephalopathy (HIE) ,ventilation and metabolic acidosis were associated with an increased risk of brain ede-ma. In the multivariate logistic regression model, HIE was associated with a greater risk of brain edema and ventilation was possibly asso-ciated with brain edema. Conclusion Brain edema detected by ultrasound examination in high risk term infants has close relationship with HIE. It suggest that there is a consistency between ultrasound results and clinic situation. The detection of brain edema by ultrasound can assist doctor in clinic practice.