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A Validated RP-LC Method for Advanced Intermediate of Rabeprazole Sodium |
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| Authors: | Srinivas Koduri S V Buchireddy Reguri Mukkanti Khagga Srinivasulu Polisetty |
| Affiliation: | 1. Centre Interdisciplinaire de Nanosciences de Marseille (CNRS-UPR 3118) Aix-Marseille Université, Campus de luminy, Case 913, 13 288, Marseille cedex 9, France 2. Kiralya, Parc Biocitech, Romainville, France 3. Fuji Silysia Chemical S.A., En Budron, 1052, Le Mont-sur-Lausanne, Switzerland |
| Abstract: | The present paper describes the development of a reversed phase liquid chromatographic method for advanced intermediate of rabeprazole sodium (RBS-1) in the presence of its impurities. Successful separation of RBS-1 from the synthetic impurities achieved on a Inertsil ODS3V C18, 150 mm × 4.6 mm column. The developed LC method was validated with respect to linearity, accuracy, precision, specificity and ruggedness. To the best of our knowledge, a validated stability indicating LC method which separates all the impurities disclosed in this investigation was not published elsewhere. |
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